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Investigations into how chemokine receptors lead to migration of cancerous cells (MUELLERU16SF)

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  • Full or part time
    Dr Mueller
  • Application Deadline
    No more applications being accepted

Project Description

The migration of cancerous cells is controlled by a number of pro-inflammatory macromolecules such as chemokines. Amongst others, CCR1 and CCR5 together with their ligands play an important role in cancer metastasis. A different chemokine receptor, CXCR4 has been strongly implicated in the metastasis of breast cancer cells. We plan to investigate the molecular basis of receptor signal transduction in the migration of different cancer cells. Understanding how these receptors lead to cell migration will provide us with novel therapeutic targets which can eventually lead to medicine which can reduce or even prevent cancer metastasis

Funding Notes

This project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources. Details of tuition fees can be found at http://www.uea.ac.uk/pgresearch/pgrfees.

A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.

References

(i) Kerr JS, Jacques RO, Moyano Cardaba C, Tse T, Sexton D, Mueller A (2013) Differential regulation of chemotaxis: Role of Gβγ in chemokine receptor-induced cell migration. Cell Signal. Volume 25, Issue 4, April 2013, Pages 729–735, doi:pii: S0898-6568(12)00352-X. 10.1016/j.cellsig.2012.12.015.
(ii) Khabbazi S, Jacques RO, Moyano Cardaba C, Mueller A (2012) Jak2 and Stat3 activation is not essential for CCL3, CCL5 or CCL8 induced chemotaxis. Cell Biochemistry and Function, in press
(iii) Moyano Cardaba, C., Jacques, R.O., Barrett, J.E., Hassell, K.M., Kavanagh, A., Remington, F.C., Tse, T., Mueller, A. (2012) CCL3 induced migration occurs independently of intracellular calcium release, Biochem Biophys Res Commun. 2012 418(1):17-21. Epub 2011 Dec 22, http://dx.doi.org/10.1016/j.bbrc.2011.12.081
(iv) Moyano Cardaba, C, Mueller A (2009) Distinct modes of molecular regulation of CCL3 induced calcium flux in monocytic cells. Biochem Pharmacol, 2009; 78; 974-982, doi:10.1016/j.bcp.2009.06.003
(v) Moyano Cardaba, C, Kerr JS, Mueller A (2008) CCR5 internalisation and signalling have different dependence on membrane lipid raft integrity. Cell Signalling, 2008; 20; 1687-1694, doi:10.1016/j.cellsig.2008.05.014

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