The Role of Rho Family GTPases in Glioma
Gliomas are the commonest form of brain tumour and the progression from low to high grade malignant glioma is associated with increased invasion and poor prognosis. Gliomas are difficult to treat and there is an urgent need to better understand factors that contribute to disease progression. The Rho family of small GTPases regulate play a pivotal role in regulating cell adhesion dependent functions such as cell migration and tumour cell invasion. Recently, we have identified that progression from low to high grade glioma is associated with one member of the Rho family called Rnd3 and this project will analyse how Rnd3 regulates progression from low to high grade glioma.
Please find additional funding text below. For further funding details, please see the ‘Funding’ section.
The School of Biosciences offers a number of UK Research Council (e.g. BBSRC, NERC) PhD studentships each year. Fully funded research council studentships are normally only available to UK nationals (or EU nationals resident in the UK) but part-funded studentships may be available to EU applicants resident outside of the UK. The deadline for applications for research council studentships is 31 January each year.
Each year we also have a number of fully funded Darwin Trust Scholarships. These are provided by the Darwin Trust of Edinburgh and are for non-UK students wishing to undertake a PhD in the general area of Molecular Microbiology. The deadline for this scheme is also 31 January each year.
All applicants should indicate in their applications how they intend to fund their studies. We have a thriving community of international PhD students and encourage applications at any time from students able to find their own funding or who wish to apply for their own funding (e.g. Commonwealth Scholarship, Islamic Development Bank).
The postgraduate funding database provides further information on funding opportunities available http://www.birmingham.ac.uk/postgraduate/funding/FundingFilter.aspx and further information is also available on the School of Biosciences website http://www.birmingham.ac.uk/schools/biosciences/courses/postgraduate/phd.aspx
Clarke K et al (2015). Inference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of Cancer. PLOS Genet. 11, e1005325.
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