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Dietary Isothiocyanates as Modulators of Ageing-Related Inflammation

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  • Full or part time
    Dr Kehinde Ross
    Dr Sexton
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

The skin is a major target of oxidative stress-mediated ageing given its exposure to ultraviolet radiation and other factors that induce the production of reactive oxygen species (ROS). Cell senescence, the loss of replicative potential, is a key feature of such ageing. Senescent cells cease to proliferate but remain metabolically active, assume a characteristic enlarged flattened morphology and express the senescence-associated cytokines. Cruciferous vegetables such as broccoli are rich in isothiocyanates such as sulforaphane (SF) that have been shown to exert anti-inflammatory and anti-oxidant effects in diverse cell types. Therefore, we have hypothesised that SF and related compounds reduce the expression of senescence-associated molecules in skin cells.
We will use oxidative stress and replicative exhaustion models of keratinocyte senescence to investigative this hypothesis. Techniques exploited will include cell culture, cytotoxicity assays, immunostaining, RNA interference, real-time PCR, Western blotting, flow cytometry and enzyme-linked immunosorbent assays (ELISAs).
Liverpool John Moores University has a comprehensive development programme for postgradaute researchers (https://www2.ljmu.ac.uk/RGSO/training/index.htm).

One of the top 3 cities to visit in the world according to the Rough Guide to 2014, Liverpool rivals the great world cities for cultural splendour, and was the first UK city outside London to be awarded the famous Blue Plaques by English Heritage. From the Royal Liverpool Philharmonic, the oldest symphony orchestra in the UK, to the world-conquering Beatles, two internationally-famous football teams, and more galleries and museums than any UK city outside of London, plus an eclectic social scene of cinemas, bars and restaurants, Liverpool is a city of endless discovery.

Applications are welcome from students that are self-funded in the UK and EU.
The studentship is open to UK or EU students who are eligible for home/EU fees. Applicants must have or expect to obtain at least an upper second class (2:1) honours degree and/or a Master’s degree in Biochemistry or a related discipline. You will also need to provide evidence of competence in English language, if English is not your first language (ILETS 6.5).

For an informal discussion, please contact Dr Kehinde Ross or Dr Darren Sexton
E-mail: [email protected] or [email protected]

Funding Notes

Applications are welcome from students that are self-funded in the UK and EU.
The studentship is open to UK or EU students who are eligible for home/EU fees. Applicants must have or expect to obtain at least an upper second class (2:1) honours degree and/or a Master’s degree in Biochemistry or a related discipline. You will also need to provide evidence of competence in English language, if English is not your first language (ILETS 6.5).

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