New Methodology in Organic Synthesis (PAGEU16SF)

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Prof P Page
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Self-Funded PhD Students Only

School of Chemistry, University of East Anglia

About This PhD Project

Project Description
Funding Notes
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References

Project Description

We are offering a PhD opportunity within the overall theme of Total Syntheses: Tagetitoxin; Tetronothiodin; Guaianolides; Lactacystin

This will involve the total synthesis of biologically active target molecules and will provide an excellent training in organic synthesis across a wide range of reaction types including:

Asymmetric Catalysis: Epoxidation, Nitrogen Transfer; Click Chemistry; Calixarenes as scaffolds for Polyfunctional Catalysis; Electrochemically Driven Catalytic Processes.

This PhD project will involve the development of new asymmetric methodology and provide an excellent training in enantioselective synthesis and associated analytical techniques.

We would like to hear from applicants interested in research in the above area.

Funding Notes

This PhD project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources.

Details of tuition fees can be found at http://www.uea.ac.uk/pgresearch/pgrfees. A bench fee of £5000 is also normally payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research.

References

1. ‘Asymmetric Epoxidation Using Binaphthyl- and Biphenyl- Derived Iminium Salt Organocatalysts Featuring Dynamically Controlled Atropoisomerism,’ P C B Page, C J Bartlett, Y Chan, D P Day, P Parker, B R Buckley, G A Rassias, A M Z Slawin, S M Allin, J Lacour, A Pinto, J. Org. Chem., 2012, 77, 6128-6138. DOI: 10.1021/jo300915u
2. ‘Harnessing Applied Potential to Oxidation in Water,’ B R Buckley, Y Chan, N Dreyfus, C E Elliott, F Marken, P C B Page, Green Chem., 2012, 14, 2221-2225. DOI: 10.1039/c2gc35238a
3. ‘Enantioselective Total Synthesis of (+)-Scuteflorin A using Organocatalytic Asymmetric Epoxidation,’ P C B Page, C J Bartlett, Y Chan, D Day, S M Allin, M J McKenzie, J. Org. Chem., 2012, 772-774.
4. ‘Alkoxyresorcin[4]arene Triflates: The Use of Palladium Catalysed Reactions in the Synthesis of Axially Chiral Derivatives with Amino- and/or Alkoxy- Substituents,’ P C B Page, T R Bygrave, Y Chan, H Heaney, V McKee, Eur. J. Org. Chem., 2011, 3016-3025.
5. ‘Enantioselective organocatalytic epoxidation driven by electrochemically generated percarbonate and persulfate,’ P C B Page, F Marken, C Williamson, Y Chan, B R Buckley, D Bethell, Adv. Synth. Catal., 2008, 350, 1149-1154.