Antibiotics have transformed medical practice, increased life expectancy and, together with vaccination, led to the near eradication of many bacterial diseases. However, overuse, including in animals, has potentiated the emergence of resistant bacteria. Such bacteria now cause millions of infections annually, with thousands of lives lost at a societal cost of billions of dollars. Moreover, the occurrence of untreatable infections is increasingly common. This disturbing trend is an immediate threat to health in every region of the world; antibiotic-resistant bacteria have the potential to affect anyone, of any age, in any country. The multiple antibiotic resistance (mar) regulon, and homologous systems, are continually implicated. Briefly, the mar operon encodes a global gene regulatory system that controls expression of genetic determinants which confer antibiotic resistance. We hypothesise that the majority of targets for MarA, and the underlying molecular mechanisms of antibiotic resistance, are undefined. This project will combine genomic tools with focused molecular biology to identify new mechanisms of antibiotic resistance and new drug targets.
For more information about Professor Grainger’s lab and research please visit: http://graingerlab.com/
You are also advised to contact Professor Grainger directly to discuss your application prior to submission.
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To find out more about studying for a PhD at the University of Birmingham, including full details of the research undertaken in each school, the funding opportunities for each subject, and guidance on making your application, you can now order your copy of the new Doctoral Research Prospectus, at: www.birmingham.ac.uk/students/drp.aspx
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This project can be funded by the BBSRC via the Midlands Integrative Biosciences Training Partnership (MIBTP, available to all students) or by the Darwin Trust of Edinburgh (specifically to support overseas students). Deadlines for applications are yet to be announced but are likely to be Deadlines: Jan 4th 2024 (for MIBTP) and Jan 7th 2024 (for Darwin Trust).
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