Examining brain connectivity alterations in people with medically intractable epilepsy

The Epilepsy Research Group (ERG) at the University of Liverpool has an international reputation for research into the causes, treatments and consequences of epilepsy. Research within the ERG covers a broad spectrum, from basic laboratory investigations to patient-focused projects, and addresses some of the most significant issues in epilepsy therapeutics (https://www.liv.ac.uk/translational-medicine/research/epilepsy/). The ERG works in close collaboration with the Walton Centre NHS Foundation Trust (www.thewaltoncentre.nhs.uk), which provides nationally renowned care services for people with epilepsy. Neuroimaging investigations constitute a crucial role in the clinical evaluation of people with epilepsy. Neuroimaging research within the ERG is lead by Dr. Simon Keller who is based in the Institute of Translational Medicine, University of Liverpool (http://www.liv.ac.uk/translational-medicine/staff/simon-keller/).

The primary focus of the proposed research will be the application of quantitative magnetic resonance (MR) diffusion tensor imaging (DTI) techniques to examine brain connectivity alterations in people with medically intractable epilepsy, and to determine whether alterations in structure and connectivity relate to treatment prognosis. The applicant will have access to neuroimaging data acquired at multiple imaging sites and will be expected to apply novel image analysis techniques to explore brain connectivity in these samples. It is expected that applicants will have image analysis experience, preferably in context of quantitative MRI projects. Basic computer programming skills (e.g. MATLAB) is desirable.

For an informal discussion on the project please contact Simon Keller ([Email Address Removed]) although applications must be made via the postgraduate admissions team in the Institute of Translational Medicine.