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Photodynamic processes and extracellular matrices: towards new approaches to tissue repair


Project Description

Photodynamic processes rely on the use of non-toxic molecules that, upon irradiation with visible light, are able to produce reactive oxygen species (ROS). When generated in biological medium, ROS can cause chemical modification to biomacromolecules (i.e., proteins, phospholipids, etc.) resulting in reversible or irreversible alterations of their functions. Our group has several projects exploring the effects of the photodynamic process on components of the extracellular matrix (i.e., glycosaminoglycans, collagen, elastin, etc.) and potential applications in wound healing and tissue regeneration.
According to the student’s interests, we will explore these applications by using a combination of approaches including synthetic preparation/modification of photosensitisers, bioconjugation strategies and biomacromolecule purification, fabrication of artificial cellular matrices, absorption and emission spectroscopy, NMR spectroscopy, mass spectrometry, HPLC, and characterisation of ROS.

Liverpool John Moores University has a comprehensive development program for postgraduate researchers (https://www2.ljmu.ac.uk/RGSO/training/index.htm).

One of the top 3 cities to visit in the world according to the Rough Guide 2014 and voted the most cultural city in the UK by Group Leisure, Liverpool with its unique attractions, exciting events, world class sport offerings, unrivalled musical heritage and famously warm welcome is the ideal place to live. As a designated UNESCO World Heritage Site, the first UK city outside London to be awarded the famous Blue Plaques by English Heritage and previously The European Capital of Culture, the city offers blockbuster exhibitions, super-sized street theatre and world-class music festivals that have catapulted the city onto the world stage. From the Royal Liverpool Philharmonic, the oldest symphony orchestra in the UK, to the world-conquering Beatles, two internationally-famous football teams, and more galleries and museums than any UK city outside of London, plus an eclectic social scene of cinemas, bars and restaurants, Liverpool is an inspirational place to work and study.

Enquires are welcome from students that have/can obtain their own funding.
You must have or expect to obtain at least an upper second class (2:1) honours degree and/or a Master’s degree in Chemistry or a related discipline. If English is not your first language and you are not an EU student, you will also need to provide evidence of competence in English language (ILETS 6.5).

For an informal discussion, please contact Dr Francesca Giuntini.
E-mail:

Funding Notes

Enquires are welcome from students that have/can obtain their own funding.
You must have or expect to obtain at least an upper second class (2:1) honours degree and/or a Master’s degree in Chemistry or a related discipline. If English is not your first language and you are not an EU student, you will also need to provide evidence of competence in English language (ILETS 6.5).

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