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The role of sulforaphane in microtubule dynamics and organisation in health and cancer (MOGENSENU16BIGC)

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  • Full or part time
    Dr Mogensen
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Colorectal cancer is one of the most common diseases in the developed world and a major cause of cancer deaths. Studies suggest that sulforaphane is a potential anti-cancer agent able to inhibit both cancer initiation and progression by affecting cell proliferation, differentiation and apoptosis. Many of these processes depend on microtubules and the aims of this project are to study the effect of sulforaphane on microtubule dynamics and organisation during gut organoids development. The gut epithelium is continually being renewed and goes through cycles of cell division, migration, differentiation and apoptosis and the in vitro gut organoid model closely mimics in vivo gut morphogenesis.

Funding Notes

This PhD studentship is funded by Big C for three years. Funding is available to UK/EU applicants only and comprises of payment of tuition fees and an annual stipend of £14,057.

Applicants should hold at least a 2:1 first degree in either Biomedicine, Biological Sciences, or related subjects.

References

i) Azarenko eta al 2008. Carcinogenesis. 29:2360-8.
ii) Goldspink et al. 2013. J Cell Sci. 126:4000-4014.
iii) Juge et al. 2007. Cell Mol Life Sci. 64:1105-27.
iv) Sato et al. 2009. Nature 459:262-265

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