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PhD position in macrocycle drug development

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  • Full or part time
    Prof Christian Heinis
  • Application Deadline
    Applications accepted all year round
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

A PhD position is available in the group of Prof. Christian Heinis at the EPFL in Lausanne (http://isic.epfl.ch/lppt). The primary focus of the research group is the development of peptide macrocycle therapeutics using novel chemical and biological techniques.

The goal of the PhD project is the development of (peptide) macrocycle therapeutics that can be administered by the oral route. This has been a longstanding goal of the pharmaceutical industry. The PhD fellow student develop novel methods to generate and screen large combinatorial libraries of (peptide) macrocycle compounds and apply them to make antagonists of therapeutic targets. The project involves combinatorial chemistry, chemical reaction development, DNA encoding, automated peptide synthesis, affinity selection & screening, ligand characterization and biological evaluation.

Applicants need to be highly motivated and able to lead a project independently. Entrance date: end of 2015 or any time in 2016.To apply for the position, please send a letter of motivation, a CV and a list of references to Prof. Christian Heinis ([email protected]).

Funding Notes

No restrictions. Full funding is secured (standard EPFL PhD salary; around 40'000 Euro per year)

References

Publications of the Heinis lab:
Chen, S., et al., Nature Chemistry, 6(11), 1009-16, 2014
Heinis, C., et al., Nature Chemical Biology, 10(9), 696-8, 2014
Heinis, C., et al., Nature Chemical Biology, 5(7), 502-7, 2009

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