• University of Pennsylvania Featured PhD Programmes
  • University of Tasmania Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • FindA University Ltd Featured PhD Programmes
  • Staffordshire University Featured PhD Programmes
  • University of Cambridge Featured PhD Programmes
  • Aberdeen University Featured PhD Programmes
University of Liverpool Featured PhD Programmes
University of Bristol Featured PhD Programmes
Imperial College London Featured PhD Programmes
Coventry University Featured PhD Programmes
University of Tasmania Featured PhD Programmes

PhD position in macrocycle drug development


Project Description

A PhD position is available in the group of Prof. Christian Heinis at the EPFL in Lausanne (http://isic.epfl.ch/lppt). The primary focus of the research group is the development of peptide macrocycle therapeutics using novel chemical and biological techniques.

The goal of the PhD project is the development of (peptide) macrocycle therapeutics that can be administered by the oral route. This has been a longstanding goal of the pharmaceutical industry. The PhD fellow student develop novel methods to generate and screen large combinatorial libraries of (peptide) macrocycle compounds and apply them to make antagonists of therapeutic targets. The project involves combinatorial chemistry, chemical reaction development, DNA encoding, automated peptide synthesis, affinity selection & screening, ligand characterization and biological evaluation.

Applicants need to be highly motivated and able to lead a project independently. Entrance date: end of 2015 or any time in 2016.To apply for the position, please send a letter of motivation, a CV and a list of references to Prof. Christian Heinis ().

Funding Notes

No restrictions. Full funding is secured (standard EPFL PhD salary; around 40'000 Euro per year)

References

Publications of the Heinis lab:
Chen, S., et al., Nature Chemistry, 6(11), 1009-16, 2014
Heinis, C., et al., Nature Chemical Biology, 10(9), 696-8, 2014
Heinis, C., et al., Nature Chemical Biology, 5(7), 502-7, 2009

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.
Email Sent

Share this page:

Cookie Policy    X