Pharmaceutical Solid form and Gel self-assembly
This proposal will target the synthesis of supramolecular gels that are “broad-brush” complementary to candidate drug substances and pharmaceutical co-crystals with a view to developing a modern crystallisation toolkit of general application in the pharmaceutical industry for the screening, analysis and identification of the solid form of drug molecules and production of seed crystals. The project will involve synthesis of gels with generic characteristics such as hydrophobic residues, common functional groups such as carboxylic acids, amides, aryl residues etc and analysis of their gelation properties The project will undertake polymorph screening experiments against a range of ‘classic’ and new test drug substances to produce and characterize new solid forms or delineate the solid forms landscape. The issue of the solid form of drug substances (active pharmaceutical ingredients, API) is of key importance to the UK pharmaceutical industry. Different crystal forms (be they polymorphs, pseudopolymorphs, salts or co-crystals) have different bioavailability and solubility characteristics. Moreover, their crystal morphology (needle, plate, block etc.) significantly affects processing and tableting behaviour. Failure to identify the most stable crystal form of a drug has led to severe problems, such as the ritonavir case in the late 1990’s.
Fully funded studentship for 39 months.
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FTE Category A staff submitted: 40.80
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