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Development of novel models to investigate the role of pathogens in the aetiology of canine periodontitis and to test therapeutic interventions

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  • Full or part time
    Dr Riggio
    Dr Nile
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

The Dental School in collaboration with colleagues at the School of Veterinary Medicine (University of Glasgow) is seeking applications from candidates for a PhD project entitled “Development of novel models to investigate the role of pathogens in the aetiology of canine periodontitis and to test therapeutic interventions”. Applicants must be overseas veterinary, biological sciences or dental graduates, ideally with an interest in veterinary research and must be fully funded (government or personal) to cover tuition fees and bench fees. Some funding is already available from The Kennel Club Charitable Trust, which will allow a reduction in the bench fees payable.

Gingivitis and periodontitis are very common clinical problems in small animal practice, with up to 80% of adult dogs affected, and are associated with chronic pain and premature tooth loss. As tooth loss increases with age, this impairs the ability of the animal to feed, with a subsequent negative effect on quality of life. Bacteria undoubtedly play a role in the pathogenesis of disease and the specificity and type of immune response is important in determining the incidence and severity of disease. The bacteria involved in the disease processes are thought to elicit characteristic cytokine responses by activating specific Toll-like receptors (TLRs). Candidate pathogens identified in a previous study in our laboratory will be assessed for their ability to induce a host immune response (activation of TLRs and inflammatory cytokines) within both in vitro cell culture models and an ex vivo rodent mandible model in a 3D culture environment. These model systems will be used to test the efficacy of existing and potentially novel treatments.

If you would like to informally discuss the project or require further information, please contact Dr Marcello Riggio: [email protected]

Formal applications can be made through the University of Glasgow online application system:
http://www.gla.ac.uk/research/opportunities/howtoapplyforaresearchdegree/#/

When applying, please choose ’MVLS-PhD’ from the drop down menu and enter the project title in the free text box.

Funding Notes

Evidence of English language proficiency (IELTS overall score of 6.5 with no less than 6.0 in any sub-test, or an equivalent qualification recognised by the University of Glasgow) must also be provided.

Funding has to be provided via a scholarship that the student must obtain themselves from their government.

How good is research at University of Glasgow in Public Health, Health Services and Primary Care?

FTE Category A staff submitted: 48.42

Research output data provided by the Research Excellence Framework (REF)

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