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Understanding neurovascular coupling and its importance in the interpretation of modern neuroimaging techniques

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  • Full or part time
    Dr J Berwick
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

During the past two decades, blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) has become the scientific technique of choice for investigating human brain function in the field of cognitive neuroscience. It exploits the local alterations in blood flow produced by changes in neural activity, termed neurovascular coupling. However, BOLD fMRI does not measure neural activity directly and hence a fundamental problem exists: how to interpret BOLD signal changes and make inferences about the neural activity that generates them. This is far from straightforward because the mechanisms linking events that produce neural changes to BOLD signaling are highly complex. For example, increased BOLD activity in a vast range of tasks and experimental conditions is interpreted as indicating areas of increased neural activity. However, many neural circuits in the brain are inhibitory and little is known about what corresponding fMRI signals are generated. Would an inhibitory neural signal be expected to generated negative BOLD for example? Consequently, multi-modal experiments that directly compare different indicators of hemodynamic activity and electrophysiological measures of neural signals are necessary if BOLD contrast is to be correctly interpreted.

Funding Notes

This is one of many projects in competition for the current funding opportunities available within the Department of Psychology. Please see here for full details: http://www.sheffield.ac.uk/psychology/prospectivepg/funding
Overseas students are welcome to apply for funding but must be able to demonstrate that they can fund the difference in the tuition fees.
Requirements: We ask for a minimum of a first class or high upper second-class undergraduate honours degree and a distinction or high merit at Masters level in psychology or a related discipline.

Related Subjects

How good is research at University of Sheffield in Psychology, Psychiatry and Neuroscience?

FTE Category A staff submitted: 34.45

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