• University of Leeds Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of Mannheim Featured PhD Programmes
  • Carlos III Health Institute Featured PhD Programmes
  • London School of Economics and Political Science Featured PhD Programmes
Ludwig-Maximilians-Universität Munich Featured PhD Programmes
University of Nottingham Featured PhD Programmes
EPSRC Featured PhD Programmes
University of Glasgow Featured PhD Programmes
University of Bristol Featured PhD Programmes

Klotho and Neurodegeneration

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Prof Brown
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Neurodegenerative diseases are a major concern as we age. Aging increases the likelihood that we will develop diseases like Alzheimer’s disease and Parkinson’s disease. Klotho is a novel β-glucuronidase that has been associated with a protective role in aging. Recent findings have suggested that there may be a change of expression of this protein in Alzheimer’s disease. In this project the student will examine the potential role of Klotho in relation to proteins known to be associated with neurodegeneration (e.g. beta-amyloid, synucleins and the prion protein). The student will use a range of cell culture and molecular biology techniques to examine expression, toxicity and molecular interactions under different expression levels of Klotho. This project will give insight into how an aging related protein effects neurodegeneration.

Funding Notes

We welcome year-round applications from Home/EU/Overseas self-funded students and applicants able to secure funding to cover all costs involved with PhD study, including living costs, tuition fees and bench fees.

References

Wang Y, Sun Z. (2009) Current understanding of klotho. Ageing Res Rev. 8,43-51.

Zeldich E, et al. (2014) The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 289, 24700-15.

How good is research at University of Bath in Biological Sciences?

FTE Category A staff submitted: 24.50

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities
Share this page:

Cookie Policy    X