Klotho and Neurodegeneration
Neurodegenerative diseases are a major concern as we age. Aging increases the likelihood that we will develop diseases like Alzheimer’s disease and Parkinson’s disease. Klotho is a novel β-glucuronidase that has been associated with a protective role in aging. Recent findings have suggested that there may be a change of expression of this protein in Alzheimer’s disease. In this project the student will examine the potential role of Klotho in relation to proteins known to be associated with neurodegeneration (e.g. beta-amyloid, synucleins and the prion protein). The student will use a range of cell culture and molecular biology techniques to examine expression, toxicity and molecular interactions under different expression levels of Klotho. This project will give insight into how an aging related protein effects neurodegeneration.
We welcome year-round applications from Home/EU/Overseas self-funded students and applicants able to secure funding to cover all costs involved with PhD study, including living costs, tuition fees and bench fees.
Wang Y, Sun Z. (2009) Current understanding of klotho. Ageing Res Rev. 8,43-51.
Zeldich E, et al. (2014) The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem. 289, 24700-15.
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FTE Category A staff submitted: 24.50
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