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Developing Peptide Inhibitors to Target Amyloid Formation in Parkinson’s Disease

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  • Full or part time
    Dr Mason
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

There are currently no therapeutic agents to control the onset of Parkinson’s disease. However, in recent years it has become established that the protein α-synuclein self associates to form misfolded ‘amyloid’ aggregates resulting in the death of dopaminergic neurons. We have developed a method that utilises a multiplexed intracellular ‘Protein-fragment Complementation Assay’ (PCA) library screening system to derive peptides capable of binding to α-synuclein and lowering associated toxicity.
We are now looking for a bright and enthusiastic student to get involved with all these aspects of research, from library creation, screening and selection to characterisation of inhibitor function. The University of Bath is well equipped with all of the instrumentation required to complete this project. You will learn many new techniques in a supportive environment using cutting-edge technologies developed at Bath.

Funding Notes

We welcome year-round applications from Home/EU/Overseas self-funded students and applicants able to secure funding to cover all costs involved with PhD study, including living costs, tuition fees and bench fees. There will be the opportunity for International conference attendance and presentation of work.

Project queries: [email protected]
More information can be found on: http://www.bath.ac.uk/bio-sci/contacts/academics/jody_mason/

To apply please send:
• CV, including full details of all University courses grades to date.
• Contact details for two academic or professional referees.
• Cover letter outlining your suitability for the project, what you hope to achieve from the PhD and your research experience.

References

Cheruvara H, Allen-Baume V.L, Kad N.M, Mason J.M. Intracellular screening of a peptide library to derive a potent peptide inhibitor of α-synuclein aggregation. J Biol Chem. 290, 7426-35 (2015).

Mason, J.M., Muller, K.M., Schmitz, M.A., and Arndt, K.M., Semirational Design of Jun-Fos Coiled coils with Increased Affinity: Universal Implications in Leucine zipper Prediction and Design. P.N.A.S. 103, 8989-8994, (2006).

How good is research at University of Bath in Biological Sciences?

FTE Category A staff submitted: 24.50

Research output data provided by the Research Excellence Framework (REF)

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