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Epigenetic control in regulating cell fate specification and oncogenic processes


Project Description

Our main research interest is to understand the mechanistic action of epigenetic control in common human diseases. We aim to identify and characterise the conserved regulatory circuits underlie human diseases such as cancer, and age-related diseases. Therefore, we use the powerful genetic model organism C. elegans to study conserved regulatory events at the chromatin level. These round worms (nematodes) share 70% of proteins encoded in the human genome. Most proteins involved in transcription and chromatin function are highly conserved. The comprehensive genetic tools (e.g. the genome-wide RNAi library), short life cycle (only 3 days), and the ease of molecular experiments (e.g. CRISPR genome editing) make C. elegans a great experimental system to address big biological questions to aid the understanding of the underlying mechanisms for human diseases.     

We currently are investigating the interplay between chromatin modifiers in the cell fate specification using functional genomic and proteomic approaches, and how this interplay impacts on the formation of pathological DNA structure leading to incorrect cell fate and human cancer  (Collaboration with Dr. Edwin Chen) 

Applicants with a strong interest in gene & development and cancer biology are encouraged to apply.

Lab website for Drs Ron Chen: http://www.ronchenlab.info and Edwin Chen http://www.edwinchenlab.com

References

Chen et al., Genome Research 24(7):1138-1146 (2014)

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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