• King Abdullah University of Science and Technology (KAUST) Featured PhD Programmes
  • Heriot-Watt University Featured PhD Programmes
  • University of Southampton Featured PhD Programmes
  • University of Manchester Featured PhD Programmes
  • FindA University Ltd Featured PhD Programmes
  • University College London Featured PhD Programmes
  • University of Birmingham Featured PhD Programmes
University of Leeds Featured PhD Programmes
University of Glasgow Featured PhD Programmes
Coventry University Featured PhD Programmes
University of Southampton Featured PhD Programmes
University of Bristol Featured PhD Programmes

Epigenetic control in regulating cell fate specification and oncogenic processes


Project Description

Our main research interest is to understand the mechanistic action of epigenetic control in common human diseases. We aim to identify and characterise the conserved regulatory circuits underlie human diseases such as cancer, and age-related diseases. Therefore, we use the powerful genetic model organism C. elegans to study conserved regulatory events at the chromatin level. These round worms (nematodes) share 70% of proteins encoded in the human genome. Most proteins involved in transcription and chromatin function are highly conserved. The comprehensive genetic tools (e.g. the genome-wide RNAi library), short life cycle (only 3 days), and the ease of molecular experiments (e.g. CRISPR genome editing) make C. elegans a great experimental system to address big biological questions to aid the understanding of the underlying mechanisms for human diseases.     

We currently are investigating the interplay between chromatin modifiers in the cell fate specification using functional genomic and proteomic approaches, and how this interplay impacts on the formation of pathological DNA structure leading to incorrect cell fate and human cancer  (Collaboration with Dr. Edwin Chen) 

Applicants with a strong interest in gene & development and cancer biology are encouraged to apply.

Lab website for Drs Ron Chen: http://www.ronchenlab.info and Edwin Chen http://www.edwinchenlab.com

References

Chen et al., Genome Research 24(7):1138-1146 (2014)

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully



Share this page:

Cookie Policy    X