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China Scholarship Council: Molecular mechanisms of neurodegeneration and therapeutic neuroprotection using new high throughput translatome technology and induced-neuronal cells derived from human patients

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  • Full or part time
    Dr Guillaume Hautbergue
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

This project is expected to open up a new scientific investigation era in the biomedical sciences using an integrated approach to identify whole cell RNA (transcriptome) and translating mRNA molecules (translatome) to characterise gene expression alteration changes at the functional protein coding level. Following partial knockdown of a specific RNA-binding factor, we have recently developed a promising therapeutic strategy to prevent neurodegeneration in vivo in a C9ORF72-related Motor Neurone Disease Drosophila model. This same knockdown strategy alleviated neurotoxicity in co-cultures of astrocytes and motor neurons derived from human patients with a new direct reprogramming method that is much faster and efficient than induced pluripotent stem cell (iPSC) technology. This project will aim at identifying the molecular mechanisms of neuronal death and protection using cutting-edge human cell culture techniques, molecular and cellular biology, biochemistry and bioinformatics approaches.

How to apply

Please complete a University Postgraduate Research Application form and attach at least two references to your application. Please select ’China Scholarship Council’ in the Scholarship section of your application. When asked to outline your research proposal, please copy and paste the above project description and supervisor name.

Please clearly state the prospective main supervisor in the respective box and select ‘Neuroscience’ as the department.

If you are shortlisted by our department then you will also need to apply to the CSC, details can be found here.

Deadline: 5pm 5th January 2015.

Funding Notes

Funding

This scholarship covers fees and stipend for Chinese students only.

Proposed start date: October 2016

Entry Requirements

The Chinese Scholarship Council programme is open to Chinese students applying to start PhD in October 2016 only.

Candidates must receive an unconditional offer to study before they will be considered for the scholarship.

Candidates must have a first or upper second class honours degree or significant research experience.

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