• Carlos III Health Institute Featured PhD Programmes
  • University of Mannheim Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of Cambridge Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • London School of Economics and Political Science Featured PhD Programmes
  • University of Bristol Featured PhD Programmes
Wellcome Trust Featured PhD Programmes
Imperial College London Featured PhD Programmes
University of Kent Featured PhD Programmes
University of Oxford Featured PhD Programmes
University of Manchester Featured PhD Programmes

Targeting cannabinoids to the gut-associated lymphoid tissue (GALT) for improved treatment of autoimmune diseases

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Dr Gershkovich
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Autoimmune diseases are conditions that are triggered by the immune system initiating an attack on the body’s own molecules. The causes of such attacks in most cases are unknown, but a number of studies suggest that they are associated with factors such as genetics, infections and environment. There are currently more than eighty different autoimmune diseases. Examples include debilitating conditions such as multiple sclerosis, systemic lupus erythematosus, arthritis and Grave’s disease.
There has been a long debate in the literature regarding the potential benefit of immunomodulatory effects of cannabinoids in the treatment of autoimmune diseases. These effects are based on the inhibition of immune cells (macrophages, T and B lymphocytes, natural killer cells) by cannabinoids via the cannabinoid receptor 2. Cannabinoids are highly lipophilic compounds. There are multiple reports that co-administration of lipophilic compounds with long-chain triglycerides (LCT) facilitates the intestinal lymphatic transport of these molecules. Lymphatic transport leads to extremely high local concentrations of lipophilic compounds in the lymph fluid and nodes. The delayed absorption of drugs when they are transported via the lymphatic system suggests that there could be several hours retention of cannabinoids in mesenteric lymph nodes following a single oral administration.
The rationale of this project is that oral administration of lipophilic cannabinoids with LCT facilitates the intestinal lymphatic transport and, thereby, creates high local concentrations of these molecules in the mesenteric lymph nodes and significant immunomodulation effect. We hypothesize that administration of lipophilic cannabinoids in conditions that facilitate lymphatic transport would result in a more efficient treatment of autoimmune diseases.
Over the last 3 years substantial in vitro and in vivo preliminary data have been generated in our laboratory. These data demonstrate the immunomodulatory activity of cannabinoids, as well as very significant intestinal lymphatic targeting with very high concentrations obtained in gut-associated lymphoid tissues (GALT).
Therefore, the aims of this PhD project will be focused on establishment of animal models of a number of autoimmune diseases, and demonstration of the efficacy of the GALT-targeting of cannabinoids in these animal models. The second half of the PhD will be focused on small-scale clinical studies that involve patients that suffer from the autoimmune disease that have been modelled in the in vivo studies.

Funding Notes

Applications are invited from self-funded students.
The project will be co-supervised by Dr Pavel Gershkovich, Professor Peter Fischer, Professor Cris Constantinescu and Professor Dave Barrett in the University of Nottingham, UK.
For informal inquiries please contact Dr Pavel Gershkovich ([email protected]).

How good is research at University of Nottingham in Allied Health Professions, Dentistry, Nursing and Pharmacy?
Pharmacy

FTE Category A staff submitted: 44.10

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities
Share this page:

Cookie Policy    X