• FindA University Ltd Featured PhD Programmes
  • Staffordshire University Featured PhD Programmes
  • Aberdeen University Featured PhD Programmes
  • University of Cambridge Featured PhD Programmes
  • University of Southampton Featured PhD Programmes
  • University of Pennsylvania Featured PhD Programmes
University of Glasgow Featured PhD Programmes
University of Bristol Featured PhD Programmes
Imperial College London Featured PhD Programmes
Peter MacCallum Cancer Centre Featured PhD Programmes
National University of Singapore Featured PhD Programmes

Pharmacokinetics and pharmacodynamics of cordycepin, a potential lead drug in osteoarthritis

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Osteoarthritis is a common cause of pain and loss of flexibility in joints. It is characterised by a loss of cartilage, changes in the bone structure and synovitis in the affected joint. Treatment options are currently largely limited to exercise, non-steroid anti-inflammatory drugs, corticosteroids, opioid pain killers and surgery.
Cordycepin (3’ deoxyadenosine) is isolated from a fungus that is used as a health food and traditional medicine throughout the Far East. We have previously shown that cordycepin has anti-inflammatory properties through its effects on polyadenylation, the last step of mRNA synthesis. The specificity of the effect of polyadenylation inhibition on inflammatory mRNAs opens up the possibility that cordycepin could be a lead drug for the treatment of inflammatory disease.
The purpose of this project is to assess the biopharmaceutical properties of cordycepin, including its pharmacokinetics and biodistribution in order to evaluate the potential of cordycepin for the treatment of osteoarthritis.
Understanding where and how cordycepin is absorbed and how it distributes around the body is very important for the future development of better analogues with higher efficacy and low toxicity. This project will also help with the design of improved formulation and administration of unmodified cordycepin, e.g. it will indicate if intra-articular injection or a combination with a low dose of other compounds could improve the response.

How good is research at University of Nottingham in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 44.10

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.
Email Sent

Share this page:

Cookie Policy    X