• London School of Economics and Political Science Featured PhD Programmes
  • University of Cambridge Featured PhD Programmes
  • University of Mannheim Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • Carlos III Health Institute Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
University of Liverpool Featured PhD Programmes
Queen’s University Belfast Featured PhD Programmes
Manchester Metropolitan University Featured PhD Programmes
University of Leeds Featured PhD Programmes
University of Manchester Featured PhD Programmes

Exploiting TP53 status to rationally design therapies to selectively target colon cancer cells

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Dr McDade
    Prof Longley
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

*FUNDING CONFIRMED*

Loss of the tumour suppressive functions of p53 occurs via mutation in greater than 50% of all human tumours. However, in contrast to most other tumour suppressors, the majority of mutations are missense mutants, which may exhibit gains-of-function ’GOF’ resulting in tumours with increased invasiveness and metastases, impaired apoptosis and resistance to therapy. p53 mutation therefore represents an attractive therapeutic target in a range of cancers.

Recent data from our lab suggests, that different genes/pathways are altered as a result of various mechanisms of p53 inactivation, resulting in addiction to these signalling pathways, which may be exploited to selectively kill cancer cells or sensitise them to existing therapeutic agents.

The aim of this project is to use a range of p53 mutated colorectal cancer models to identify novel strategies exploiting different p53 related dependencies that we have recently identified from extensive genomic analyses with a particular focus on ubiquitin and epigenetic modifiers.

REQUIREMENTS

Candidates should have or expect to obtain a 2:1 or higher Honours degree or equivalent in a relevant biomedical or life sciences subject.

English Language

Candidates applying from countries where the first language is not English should produce evidence of their competence through a qualification such as IELTS or TOEFL score.

The minimum recommended score for the School of Medicine, Dentistry and Biomedical Science is:
• IELTS score of 6.0 with not less than 5.5 in each of the four component elements of listening, reading, speaking and writing taken within the last 2 years;
• TOEFL score of 80+ (internet basted test), taken within the last 2 years, with minimum component scores of; Listening 17, Reading 18, Speaking 20, Writing 17);
• A valid Certificate of Proficiency in English grade A or B;
• A valid Certificate of Advanced English grade A; or
• A first or upper second class honours degree from a university based in the UK, Republic of Ireland or other suitably quality assured location in a country deemed by the UK Border Agency to be majority English speaking.

For a list of English Language qualifications also accepted by the School and University please see the following link:
http://www.qub.ac.uk/home/StudyatQueens/InternationalStudents/EnglishLanguageRequirements/

The English Language Unit (ELU) offers both pre-sessional and in-sessional courses in English for academic purposes and study skills. Courses vary in length and full information can be obtained from the ELU http://www.qub.ac.uk/tefl/

Funding Notes

*FUNDING CONFIRMED*

DEL Research Studentships

Eligibility for both fees and maintenance (£14,057 for 2015/16, 2016/17 TBC) depends on the applicants being either an ordinary UK resident or those EU residents who have lived permanently in the UK for the 3 years immediately preceding the start of the studentship.

Non UK residents who hold EU residency may also apply but if successful may receive fees only.

For further details re eligibility criteria (including academic, citizenship and residency criteria) please click on the following link: http://www.delni.gov.uk/index/further-and-higher-education/higher-education/studentfinance/he-student-info-postgrad-finance.htm

References

Please visit the School of Medicine, Dentistry and Biomedical Sciences, Centre for Cancer Research and Cell Biology, website for further details about the Centre:

http://www.qub.ac.uk/research-centres/CentreforCancerResearchCellBiology/

When applying, please choose 'MEDICINE' as your subject area/School.

Related Subjects

Share this page:

Cookie Policy    X