Exploiting TP53 status to rationally design therapies to selectively target colon cancer cells
Dr S McDade
Prof D Longley
No more applications being accepted
Funded PhD Project (European/UK Students Only)
Loss of the tumour suppressive functions of p53 occurs via mutation in greater than 50% of all human tumours. However, in contrast to most other tumour suppressors, the majority of mutations are missense mutants, which may exhibit gains-of-function ’GOF’ resulting in tumours with increased invasiveness and metastases, impaired apoptosis and resistance to therapy. p53 mutation therefore represents an attractive therapeutic target in a range of cancers.
Recent data from our lab suggests, that different genes/pathways are altered as a result of various mechanisms of p53 inactivation, resulting in addiction to these signalling pathways, which may be exploited to selectively kill cancer cells or sensitise them to existing therapeutic agents.
The aim of this project is to use a range of p53 mutated colorectal cancer models to identify novel strategies exploiting different p53 related dependencies that we have recently identified from extensive genomic analyses with a particular focus on ubiquitin and epigenetic modifiers.
Candidates should have or expect to obtain a 2:1 or higher Honours degree or equivalent in a relevant biomedical or life sciences subject.
Candidates applying from countries where the first language is not English should produce evidence of their competence through a qualification such as IELTS or TOEFL score.
The minimum recommended score for the School of Medicine, Dentistry and Biomedical Science is:
• IELTS score of 6.0 with not less than 5.5 in each of the four component elements of listening, reading, speaking and writing taken within the last 2 years;
• TOEFL score of 80+ (internet basted test), taken within the last 2 years, with minimum component scores of; Listening 17, Reading 18, Speaking 20, Writing 17);
• A valid Certificate of Proficiency in English grade A or B;
• A valid Certificate of Advanced English grade A; or
• A first or upper second class honours degree from a university based in the UK, Republic of Ireland or other suitably quality assured location in a country deemed by the UK Border Agency to be majority English speaking.
For a list of English Language qualifications also accepted by the School and University please see the following link:
The English Language Unit (ELU) offers both pre-sessional and in-sessional courses in English for academic purposes and study skills. Courses vary in length and full information can be obtained from the ELU http://www.qub.ac.uk/tefl/
DEL Research Studentships
Eligibility for both fees and maintenance (£14,057 for 2015/16, 2016/17 TBC) depends on the applicants being either an ordinary UK resident or those EU residents who have lived permanently in the UK for the 3 years immediately preceding the start of the studentship.
Non UK residents who hold EU residency may also apply but if successful may receive fees only.
For further details re eligibility criteria (including academic, citizenship and residency criteria) please click on the following link: http://www.delni.gov.uk/index/further-and-higher-education/higher-education/studentfinance/he-student-info-postgrad-finance.htm
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When applying, please choose 'MEDICINE' as your subject area/School.