Exploring the therapeutic potential of mesenchymal stem cells in a model of chronic inflammatory lung disease
Dr S Weldon
Dr A Krasnodembskaya
No more applications being accepted
Awaiting Funding Decision/Possible External Funding
*SUBJECT TO FUNDING*
For incurable chronic inflammatory lung diseases, such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD), current therapies are primarily targeted at modulating inflammation or infection. Mesenchymal stem cell (MSC) therapy represents a promising new hope for the cure of such diseases through their immunomodulatory, anti-bacterial, and regenerative potential. The overall objective of this project is to investigate the therapeutic potential of human bone marrow-derived MSCs in a model of chronic lung disease. To achieve this objective, we will answer 2 research questions: (1). Do MSCs exert a beneficial effect on chronic inflammatory lung disease? (2). Do MSCs influence bacterial infection in the βENaC-Tg mouse model? To measure the impact of stem cell therapy on our model we will evaluate a number of indices of lung disease including inflammation, lung damage and mucus plugging. Techniques to be used will include histology, flow cytometry, RT-PCR, ELISA and Western blotting.
Candidates should have or expect to obtain a 2:1 or higher Honours degree or equivalent in a relevant biomedical or life sciences subject.
Candidates applying from countries where the first language is not English should produce evidence of their competence through a qualification such as IELTS or TOEFL score.
The minimum recommended score for the School of Medicine, Dentistry and Biomedical Science is:
• IELTS score of 6.0 with not less than 5.5 in each of the four component elements of listening, reading, speaking and writing taken within the last 2 years;
• TOEFL score of 80+ (internet basted test), taken within the last 2 years, with minimum component scores of; Listening 17, Reading 18, Speaking 20, Writing 17);
• A valid Certificate of Proficiency in English grade A or B;
• A valid Certificate of Advanced English grade A; or
• A first or upper second class honours degree from a university based in the UK, Republic of Ireland or other suitably quality assured location in a country deemed by the UK Border Agency to be majority English speaking.
For a list of English Language qualifications also accepted by the School and University please see the following link:
The English Language Unit (ELU) offers both pre-sessional and in-sessional courses in English for academic purposes and study skills. Courses vary in length and full information can be obtained from the ELU http://www.qub.ac.uk/tefl/
*SUBJECT TO FUNDING*
DEL Research Studentships
Eligibility for both fees and maintenance (£14,057 for 2015/16, 2016/17 TBC) depends on the applicants being either an ordinary UK resident or those EU residents who have lived permanently in the UK for the 3 years immediately preceding the start of the studentship.
Non UK residents who hold EU residency may also apply but if successful may receive fees only.
For further details re eligibility criteria (including academic, citizenship and residency criteria) please click on the following link: http://www.delni.gov.uk/index/further-and-higher-education/higher-education/studentfinance/he-student-info-postgrad-finance.htm
Please visit the School of Medicine, Dentistry and Biomedical Sciences, Centre for Infection and Immunity, website for further details about the Centre:
When applying, please choose 'MEDICINE' as your subject area/School.