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Fungal Cell Biology (Marie-Curie Early Stage Researcher Fellowship): molecular mechanisms of polarized growth and cell morphogenesis in the budding yeast Saccharomyces cerevisiae and human pathogenic yeast Candida albicans

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  • Full or part time
    Dr Robert Arkowitz
  • Application Deadline
    Applications accepted all year round

Project Description

3-year PhD fellowship at the University of Nice-Sophia Antipolis, France

We are seeking a motivated and enthusiastic student for doctoral thesis research on the molecular mechanisms of polarized growth and cell morphogenesis in the budding yeast Saccharomyces cerevisiae and human pathogenic yeast Candida albicans. The project will start in 2016 and is directed at understanding the roles of a range of G-proteins and phospholipids in external-signal mediated polarized growth including during the mating process and the yeast to filamentous growth transition. This work will be carried out at the CNRS/INSERM Institute of Biology Valrose in Nice, France (http://ibv.unice.fr/EN/equipe/arkowitz.php). A range of cell biological, molecular, and biochemical techniques will be used, in addition to state of the art live-cell imaging methods, taking advantage of extensive on site communal microscopy facilities. The project is part of a Marie Curie ITN consortium of 11 European academic and industrial laboratories working at the forefront of research on polarity on a project entitled “Principles of Polarity – Integrating genetic, biophysical and computational approaches to understand cell and tissue polarity” (PolarNet) and will provide extensive training opportunities.
See http://polarnet-itn.eu

Funding Notes

A generous salary and mobility allowance will be provided for 3 years.

Candidates should have a Master’s degree or equivalent in a relevant field, including cell biology, biochemistry, microbiology, molecular biology, or genetics and have laboratory experience working with microorganisms. Motivation, enthusiasm and ability to communicate in English and interact with lab members are critical. Candidates must not have resided in France for more than 12 months in the past 3 years.

To apply: Candidates should send a motivation letter and a curriculum vitae with names and contact information for 2 referees to:
Rob Arkowitz ([email protected]).

References

Ghugtyal, Garcia-Rodas, Seminara, Schaub, Bassilana & Arkowitz. Phosphatidylinositol-4-phosphate-dependent membrane traffic is critical for fungal filamentous growth. Proc. Nat. Acad. Sci. U S A. 2015, 112: 8644-9.

Corvest, Bogliolo, Follette, Arkowitz & Bassilana. Spatiotemporal regulation of Rho1 and Cdc42 activity during Candida albicans filamentous growth. Mol. Microbiol. 2013, 89: 626-48.

Guillas, Vernay, Vitagliano & Arkowitz. Phosphatidylinositol 4,5-bisphosphate is required for invasive growth in Saccharomyces cerevisiae. J. Cell Sci. 2013, 126: 3602-14.

Vernay, Schaub, Guillas, Bassilana & Arkowitz. A steep phosphoinositide-bis-phosphate gradient forms during fungal filamentous growth. J. Cell. Biol. 2012, 198: 711-30.

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