Inflammatory diseases are characterised by the migration of leukocytes into the affected tissue. This is caused by chemokines. By targeting interactions of chemokines with endothelial cells using small peptides and larger molecules we have been able to inhibit leukocyte migration. The project will continue on with this work to design small and large peptides that could be future anti-inflammatory therapies. This will be using cell culture, cell biology, inflammation assays in vitro and potentially in vivo.
When applying please select "PhD in Oral and Dental Sciences" within the Faculty of Health Sciences.
Kehoe O, Kalia N, Boyes C, King S, Reizes O, Williams A, Patterson A, Middleton J (2014) Syndecan-3 is selectively pro-inflammatory in the joint and contributes to antigen-induced arthritis in mice. Arthritis Research and Therapy 16: R48 (pp1-10)
Whittall C, Kehoe O, King S, Rot A, Patterson A, Middleton J (2013) A chemokine self-presentation mechanism involving endothelial surface microstructure formation. Journal of Immunology 190 (4): 1725-36.