• University College London Featured PhD Programmes
  • FindA University Ltd Featured PhD Programmes
  • Heriot-Watt University Featured PhD Programmes
  • University of Birmingham Featured PhD Programmes
  • King Abdullah University of Science and Technology (KAUST) Featured PhD Programmes
  • University of Southampton Featured PhD Programmes
  • University of Manchester Featured PhD Programmes
University of Liverpool Featured PhD Programmes
University of Southampton Featured PhD Programmes
Cranfield University Featured PhD Programmes
EPSRC Featured PhD Programmes
University of Liverpool Featured PhD Programmes

Role of periodontitis on macrophage polarisation and subsequent association in cardiovascular disease

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Prof S George
    Dr J Johnson
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

About This PhD Project

Project Description

Periodontitis is associated with an increased risk of atherosclerosis which leads to coronary artery disease and death (1). A wealth of clinical and epidemiological data substantiates a central role of inflammation in atherosclerosis. The macrophage plays a central role (2). They are a major source of pro-inflammatory cytokines and are implicated in the earliest events of plaque initiation as well as later stages of progression. Triggered by initial endothelial dysfunction, monocytes influx into the intima where they differentiate into macrophages and take up modified lipids to become foam cells. The continued inflammatory response leads to plaque formation, enhanced by impairment of apoptotic macrophage clearance; contributing to plaque instability and subsequent rupture.
Macrophages polarise into different subsets and these have been identified in animal models and human samples (3). This PhD will focus on macrophage polarisation in periodontitis and coronary artery disease. It will exploit monocyte/macrophage samples from patients with periodontitis and coronary disease and tease out the potentially mechanisms underlying enhanced coronary artery disease in periodontitis patients. We will also determine whether exposure to different bacterial strains affects polarisation.
The hypothesis for this PhD is:
Compared to the general population periodontitis patients show greater polarisation of monocyte/macrophage towards a pro-atherogenic, inflammatory phenotype due to exposure to periodontal bacteria.
For this PhD, the student will undertake in vitro experiments on samples obtained from the following patients and healthy volunteers. They will gain valuable experience in a number of techniques including cell culture, flow cytometry, immunocytochemistry, Q-PCR, Western blotting and histology.

When applying please select ’Medicine PhD’ within the Faculty of Health Sciences.

Related Subjects

Share this page:

Cookie Policy    X