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PhD Studentship – Investigating the role of neuroinflammation on the accumulation and spread of tau pathology.

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  • Full or part time
    Dr Teeling
    Dr Deinhardt
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Alzheimer’s disease (AD), the most common form of dementia is neuropathologically characterised by amyloid beta deposition and neurofibrillary tangles (NFTs). NFTs are intracellular aggregates composed of hyperphosphorylated tau protein and occur in a well-defined stereotypical fashion, first affecting the entorhinal cortex, followed by the hippocampus and finally the neocortex. This characteristic accumulation and spread of tau pathology is termed tau propagation (TP) and has been replicated using in vitro and in vivo models; however, the exact mechanisms that drive TP are still unknown. Increasing evidence suggests a critical role of neuroinflammation in AD. In this study we aim to test the hypothesis that local and/or systemic inflammation can accelerate the accumulation and spread of tau pathology thus contributing to disease pathogenesis.

Funding Notes

This MRC CASE studentship is a collaborative project between The University of Southampton and Eli Lilly (based in Surrey). We are looking for a highly motivated candidate who will benefit from training in a range of molecular, biochemical, in vivo and ex vivo techniques. The project is funded for 4 years and welcomes applicants from the UK and EU who have or expect to obtain at least an upper second class degree in Biological Sciences or allied subjects. Funding will cover fees and a stipend at a supplemented research council rate of £ 17,057 per annum.

References

Relevant literature:
Ahmed Z et al A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity. Acta Neuropathol. 2014;127(5):667-83.

Püntener U et al Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia. J Neuroinflammation. 2012;9:146. doi: 10.1186/1742-2094-9-146.

Applications for an MPhil/PhD in Biological Sciences should be submitted online at https://studentrecords.soton.ac.uk/BNNRPROD/bzsksrch.P_Login?pos=4973&majr=4973&term=201516.

Please place Jessica Teeling’s name in the field for proposed supervisor.

General enquiries should be made to [email protected] Any queries on the application process should be made to [email protected]

Due to funding restrictions this position is only open to UK/EU applicants.

Applications will be considered in the order that they are received, and the position will be considered filled when a suitable candidate has been identified.

The University of Southampton and the Centre for Biological Sciences both hold an Athena Swan Bronze Award, demonstrating their commitment to provide equal opportunities and to advance the representation of women in STEM/M subjects: science, technology, engineering, mathematics and medicine. Due consideration will be given to applicants who have taken a career break. University benefits include onsite childcare facilities, state-of-the-art on-campus sports, arts and culture facilities, a full programme of events and a range of staff discounts.

How good is research at University of Southampton in Biological Sciences?

FTE Category A staff submitted: 34.80

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities
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