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ENLIGHT-TEN - European Network Linking Informatics and Genomics of Helper T Cells PhD Position

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  • Full or part time
    Ms C Soeiro
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

Call for an Early Stage Researcher- PhD Position

The Instituto de Medicina Molecular in Lisbon (iMM Lisboa) is a leading European research institute with cutting edge facilities and a stimulating multinational environment.

A PhD position is open at Luis Graca Laboratory as part of the European Network Linking Informatics and Genomics of Helper T cells (ENLIGHT-TEN) consortium, which is a Marie Sklodowska-Curie Innovative Training Network (ITN-ETN) funded in the framework of the HORIZON 2020 program.

The mission of ENLIGHT-TEN is to provide cross-disciplinary training in T cell immunology and big data analysis in order to train a new generation of researchers to exploit the power of emerging technological platforms.

The Luis Graca Laboratory has been interested in the study of Foxp3+CD4+ regulatory T cells (Tregs) and other populations of regulatory lymphocytes, in the prevention of autoimmunity, transplant rejection and allergy. The group has been interested in mechanisms that allow protection from transplant rejection (J Exp Med 2002, Nature Immunol 2002) or that prevent immunogenicity of therapeutic molecules, such as clotting factors in hemophilia (Blood 2013). The Luis Graca Lab has recently identified the characteristics of specialized populations of regulatory iNKT cells and T follicular cells that express Foxp3 (J Immunol 2010, 2011).

ENLIGHT-TEN has developed a cross-disciplinary, high-quality educational program to provide all its PhD students with specialist high-level research training, a broad scientific skill set and experience in both academic and industrial working environments. In addition to excellent research skills, our training program will also offer training in team-leading abilities, project management and entrepreneurship to supplement and complement the university-based PhD education.

ENLIGHT-TEN consists of ten beneficiaries and six partners from eight European countries, bringing a balanced portfolio of expertise bridging in-depth knowledge of T cell differentiation and pathophysiology of autoimmune and allergic diseases, through to bioinformatic analysis of large data sets. This strong network of academic and industrial partners ensures that ENLIGHT-TEN's early stage researchers (ESR) will be extremely well placed to successfully compete for academic or industrial life science-related positions, and to drive research and innovation within the European Research Area.

More information is available at: http://www.enlight-ten.eu

The PhD student will perform his/her main research activity at the iMM Lisboa at Luis Graca Laboratory. In the same time he/she will be highly connected with the ENLIGHT-TEN consortium. As part of the program, the student will attend summer schools on relevant topics and annual scientific meetings of the consortium. The PhD student will also spend some months in 3 other labs of the consortium to learn new technologies, leading to a strong background in bioinformatics and immunology.

The successful PhD candidate will study the biology of T follicular helper (Tfh) cells in the course of adaptive immune responses leading to production of different classes of antibodies. The proposal will use mouse models of disease as well as primary tissue from human patients. A significant part of the project will consist in the generation and analysis of big data (RNA-Seq) obtained from defined T cell subsets. The ultimate objective consists on the identification of unique characteristics of Tfh function related to different types of adaptive immune response that may lead to the development of novel therapeutic strategies.

Eligibility Criteria:
1. The candidate should hold a Master degree in Immunology, Bioinformatics or related disciplines prior to the appointment date
2. Not have resided in Portugal for more than 12 months in the 3 years prior to the appointment date and not have carried out their main activity (work, studies, etc.) in Portugal
3. Be an ‘early stage researcher’ (i.e. in the first four years of his/her research career and not have a doctoral degree)
4. iMM Lisboa welcomes candidates of any nationality, irrespective of gender, age, race or ethnic background.

Required documents:
- Motivation letter
- Detailed Curriculum Vitae
- Contact details of two referees

Applications should be sent Human Resources through the email [email protected], indicating the reference “ENLIGHT-TEN - Luis Graca Lab” as subject.

The results will be published at https://imm.medicina.ulisboa.pt/en/job-opportunities/results/ and posted at the entrance lobby of the Institute.

Funding Notes

The successful candidate will be employed for a maximum of 36 months (full time) and will receive an annual salary package according to the allowance amounts defined in the rules for Early Stage Researchers (ESRs) EU Marie Skłodowska-Curie Actions Innovative Training Networks (ITN).

• Living allowance – 33.252, 12€
• Mobility allowance – 7.200€
• Family allowance – 6.000€ (if applicable)

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