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Investigation into the potential of using different delivery systems of cultured oral keratinocytes as a possible treatment for mucosal defects

Project Description

The overall aim of the project is to investigate the possibility of being able to remove a small biopsy of a patients oral mucosa from a suitable site, expand the numbers of keratinocytes in culture, before seeding these cells onto a suitable delivery system and reimplanting into the patient over their mucosal defect.

The project will involve establishing cultures of human oral keratinocytes from different sites within the mouth, growing these cells on feeder layers of fibroblasts before digestion of the cells and reseeding onto different delivery substrates. To determine the feasibility of such an approach, keratinocyte expression of cytokeratins will be assessed both before and after seeding onto the delivery substrates using immunohistochemistry and RT-PCR, to examine whether the cells’ phenotype has been maintained from the particular isolation site. These delivery substrates, seeded with keratinocytes will be maintained as so-called organotypic cultures for defined periods and cell viability and proliferation will be monitored and optimised.

The project therefore will combine a wide range of cell culture and molecular biological approaches in addition to a sound general training in research.

Funding Notes

We have a thriving international Researcher community and encourage applications from students of any nationality able to fund their own studies (i.e. through Government scholarship schemes), or who wish to apply for their own funding (e.g. Commonwealth Scholarships, Islamic Development Bank International PhD Scholarships, China Scholarship Council).

At present, we would only consider applications from prospective students with:
- a good biomedical degree (minimum of a 2:1)
- a source of funding to cover tuition fees and bench fees.

How good is research at University of Birmingham in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 15.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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