Wellcome Trust Featured PhD Programmes
Birkbeck, University of London Featured PhD Programmes
University of East Anglia Featured PhD Programmes
University of Kent Featured PhD Programmes
Cardiff University Featured PhD Programmes

A potential role for Epithelial Mesenchymal Trans differentiation (EMT) in the Pathogenesis of Periodontal Disease


Project Description

Periodontitis is a ubiquitous chronic inflammatory disease that destroys the supporting structures of teeth; the most common form is chronic periodontitis which if untreated results in the breakdown of soft tissues and bone, ultimately leading to tooth loss. Periodontal disease has also been associated with a range of systemic diseases including diabetes, cardiovascular disease and rheumatoid arthritis, with successful management of periodontitis associated with improved systemic disease outcomes. The disease is initiated by plaque bacteria present in a biofilm at and below the gingival margin, however the subsequent tissue damage that characterises this disease is the result of an aberrant and exaggerated host response within susceptible individuals (Matthews et al, 2006). The periodontal lesion is characterised by non-resolving chronic inflammation with frustrated healing and breakdown of the soft / hard tissue interface resulting in tissue loss.

Epithelial-mesenchyme Trans differentiation (EMT) has yet to be investigated for its potential role in the pathogenesis of periodontal disease. EMT is well characterised in other disease areas and results in frustrated healing and fibrosis both characteristic of the periodontal lesion. Induction of EMT within oral tissues may result in disruption of repair mechanisms and break down of the epithelial barrier allowing disease progression. Many of the previously reported risk factors which promote EMT at other disease sites are also relevant to periodontitis and include elevated levels of glucose, growth factors/cytokines, tobacco smoke and bacteria. This study aims to develop 2D and 3D oral keratinocyte in vitro EMT models using cell lines and primary cells. The induction of oral EMT by periodontitis risk factors in these systems will be assessed using a range of cellular, molecular and biochemical analyses. Potential inhibition of oral EMT will be determined following administration of a range of molecules and chemicals, such as antioxidants and vitamins. The pharmaceutical industry is also currently developing inhibitors for EMT which may have clinical application in periodontitis treatment.

At present, we would only consider applications from prospective students with:
- a good (bio)medical degree, with interests in any of the areas outlined above,
- good command of the English language as outlined in the postgraduate prospectus,
- a source of funding to cover tuition fees and bench fees.

To be considered for this studentship, please send the following documents to :
• A detailed CV, including your nationality and country of birth;
• Names and addresses of two referees;
• A covering letter highlighting your research experience/capabilities;
• Copies of your degree certificates with transcripts;
• Evidence of your proficiency in the English language, if applicable.

Funding Notes

We have a thriving international Researcher community and encourage applications from students of any nationality able to fund their own studies (i.e. through Government scholarship schemes, self-funding), or who wish to apply for their own funding (e.g. Commonwealth Scholarships, Islamic Development Bank International PhD Scholarships, China Scholarship Council, etc).

Related Subjects

How good is research at University of Birmingham in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 15.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2018
All rights reserved.

Let us know you agree to cookies

We use cookies to give you the best online experience. By continuing, we'll assume that you're happy to receive all cookies on this website. To read our privacy policy click here

Ok