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Therapeutic application of dental pulp stem cells for neural repair and regeneration

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Dental pulp stem cells (DPSCs) are neural crest-derived mesenchymal stem cells that are capable of differentiating along various cell lineages. DPSCs are increasingly gaining interest as cell therapy for neuronal tissue regeneration. DPSC may be able to differentiate into neuronal cell types, but accumulating evidence also indicates that DPSCs are effective to provide neuroprotection and nerve repair via paracrine-mediated actions involving a range of secreted neurotrophic growth factors. However, the precise mechanisms by which DPSCs confer their therapeutic benefits have not yet been fully elucidated. This project represents a multidisciplinary research that will examine in further detail the application and role of DPSC and their secretome in neuroprotection and neural repair using specialised in vitro and in vivo models of nerve injury. The PhD study will also investigate optimisation of pre-culture and cell delivery conditions to achieve maximum neurogenic & neurotrophic potential. It is anticipated that this study will contribute to the development of novel stem cell-based therapies for central nervous system and retinal neuronal repair.

Funding Notes

We have a thriving international researcher community and encourage applications from students of any nationality able to fund their own studies (Government scholarship), or who wish to apply for their own funding (e.g. Islamic Development Bank International PhD Scholarships, China Scholarship Council).

At present, we would only consider applications from prospective students with:
- a good biomedical degree, with interests in any of the areas outlined above,
- good command of the English language as outlined in the postgraduate prospectus,
- a source of funding to cover tuition fees and bench fees.

References

Mead B and Scheven BA (2015) Mesenchymal stem cell therapy for retinal ganglion cell neuroprotection and axon regeneration. Neural Regen Res. 10:371-373
Mead B, Logan A, Berry M, Leadbeater W, Scheven BA (2014) Adult stem cell treatment for central nervous system injury. Current Tissue Engineering. 3: 93-101
Mead B, Logan A, Berry M, Leadbeater W, Scheven BW (2014) Paracrine-mediated neuroprotection and neuritogenesis of axotomised retinal ganglion cells by human dental pulp stem cells: comparison with human bone marrow and adipose-derived mesenchymal stem cells. PloS One 9: e109305.

Related Subjects

How good is research at University of Birmingham in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 15.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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