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Synthesis of Group B Streptococcus type V oligosaccharides for vaccine development

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  • Full or part time
    Prof Luigi Lay
    Dr Polito
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

The synthesis of Group B Streptococcus type V (GBS PSV) oligosaccharide fragments will be the major task of the ESR selected with this call. GBS is one of the most common cause of life-threatening bacterial infections, especially in infants. Recent epidemiological studies suggested that, in order to achieve a 95% population coverage in Europe and USA, it is necessary to combine at least five serotypes (Ia, Ib, II, III and V) in a multivalent vaccine. The repeating unit of PSV consists of a heptasaccharide, and the fellow will be engaged in the synthesis of a library of sub-structures of this oligosaccharide. These glycans will be used for glycan-array studies and structural studies with specific anti PSV antibodies.
Planned secondments for this job are in Manchester (University of Manchester, UK), in Berlin (Glycouniverse, DE), and in Derio Vizcaya (CIC bioGUNE, ES).
The fellow must not have resided in the country where the research training activities will take place for more than 12 months in the 3 years immediately prior to the recruitment date (and not have carried out their main activity (work, studies, etc.) in that country).
Experience eligibility requirement: Eligible applicants must have less than 4 years research experience (Early Stage Researcher) at the signature of the contract (measured from the time the Master’s degree has been obtained).Eligible applicants must not have a PhD yet.

Funding Notes

Applications for this position must be sent to Prof. Luigi Lay ([email protected]) within 15th February 2016.
Applicants must strictly follow the application procedure available at www.glycovax.eu (ESR 2 project)
Applications not in compliance with this procedure will not be considered.

Applications from qualified female researchers are strongly encouraged.

The ESR will be contractually employed by the University of Milan and will be covered under the social security scheme. He or she will receive a Monthly Living Allowance plus a Mobility Allowance compliant with the applicable EC Marie Skłodowska-Curie Actions-ITN general conditions.

References

A suitable background for the open position includes synthesis and structural characterization of carbohydrates and oligosaccharides.
A basic background in biochemistry will be also appreciated

You can find more information about GLYCOVAX network at www.glycovax.eu
You can find more information about Prof. Luigi Lay’s group at http://users.unimi.it/luigilaygroup

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