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Examining the role of adipokines in the prothrombotic state of metabolic syndrome

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  • Full or part time
    Dr Rivero
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

About This PhD Project

Project Description

To celebrate the University's research successes, the University of Hull is offering this project supported by a full-time UK/EU PhD Scholarship or International Fees Bursary. It is one of a cluster of projects available as part of a significant investment into new and emerging areas of platelet research at Hull York Medical School's Hull campus
.
Closing date: - 29th February 2016.
Studentships will start on 26th September 2016
Supervisor: Dr Francisco Rivero (contact [email protected]) with Dr Roger Sturmey and Professor Khalid Naseem

Mounting evidence suggests that inflammation participates in the pathogenesis of type 2 diabetes (T2D), with immunomodulatory strategies for treating this condition being currently explored. Cells and mediators of the immune system have been found altered in metabolic syndrome (diabetes and obesity) in various tissues. In T2D patients platelets circulate in a hyperactivated state and platelets themselves contribute to sustaining the inflammatory processes that are at the root of T2D. Metabolic syndrome is accompanied by abnormal release of adipokines (resistin, leptin, visfatin, adiponectin and others) by the adipose tissue. Resistin has received particular attention as a potential link between inflammation and metabolic disease.

Despite the great interest in resistin as a participant in the pathogenesis of metabolic syndrome, virtually no studies have addressed its role in modulating platelet function and potentially contributing to the prothrombotic state. Two of the proposed resistin receptors, TLR-4 and CAP1, are expressed in platelets and are intimately linked with inflammatory responses. We hypothesise that resistin shifts platelets into a prothrombotic state by interfering with the signalling and metabolic routes that control platelet activation. The student will investigate this by studying the effects of resistin on an array of platelet functions, including glucose and oxidative metabolism, and will dissect the signalling pathways that mediate those effects.

The project will offer an excellent opportunity for training in the use of a wide spectrum of cutting edge cell, molecular biology and biochemistry techniques, including flow cytometry, immunoblotting, fluorescence microscopy and metabolic profiling. In addition, there will be scope within the project to translate our findings to in vivo patho-physiological conditions of insulin resistance and other metabolic conditions. The student will join a team of a post-doctoral scientist and other PhD students who use multidisciplinary approaches to characterise the molecular mechanisms regulating platelet function. The team is embedded in a research environment with wide expertise in platelet biology, cell biology and metabolism.

To apply for this post please click on the Apply button below.

In order to qualify for this scholarship you will require an undergraduate degree with at least a 2.1, or equivalent in a relevant subject.
Full-time UK/EU PhD Scholarships will include fees at the ‘home/EU' student rate and maintenance (£14,057 in 2015/16) for three years, dependent on satisfactory progress.

Full-time International PhD Fee Bursaries will include full fees at the International student rate for three years, dependent on satisfactory progress.
PhD students at Hull York Medical School follow modules for research and transferable skills development and gain a Masters level Certificate, or Diploma, in Research Training, in addition to their research degree.

Successful applicants will be informed of the award as soon as possible and by 30th April 2016 at the latest.
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