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Modulation of osteoblast responses to differently formulated bone cements


Project Description

The aim of the project is to investigate how different formulations of bone cement affect the behaviour and gene expression of both osteoblasts and bone marrow cells. The project will focus upon ways in which the osteoblast phenotype may be promoted and whether inclusion of different arrays of proteins influence the response.

Funding Notes

We have a thriving international Researcher community and encourage applications from students of any nationality able to fund their own studies (i.e. through Government scholarship schemes), or who wish to apply for their own funding (e.g. Commonwealth Scholarships, Islamic Development Bank International PhD Scholarships, China Scholarship Council).

At present, we would only consider applications from prospective students with:
- a good biomedical degree (minimum of a 2:1)
- a source of funding to cover tuition fees and bench fees.

References

Primary bone-derived cell colonization of unconditioned and pre-conditioned Bioglass 45S5 surfaces in vitro. Mortin LA, Shelton RM. Journal of Materials Science: Materials in Medicine, 14 (4): 297-305, 2003.
Evaluation of sodium alginate for bone marrow cell tissue engineering. L Wang, RM Shelton, P.R. Cooper, M Lawson, JT Triffitt, JE Barralet. Biomaterials, 24, (20): 3475-3481, 2003.
Homogeneous octacalcium phosphate precipitation: Effect of temperature and pH. Y Liu, RM Shelton, J.E. Barralet. Key Engineering Materials, 254-2, 79-82, 2004.
Adhesion and growth of bone marrow stromal cells on modified alginate hydrogels. MA Lawson, JE Barralet, L Wang, RM Shelton, JT Triffitt. Tissue Engineering 10 (9-10), 1480-1491, 2004.
Comparison of bone marrow cell growth on 2D and 3D alginate hydrogels. JE Barralet, L Wang, MA Lawson, JT Triffitt, PR Cooper, RM Shelton Journal of Materials Science: Materials in Medicine 16, (6), 515-519, 2005.
Bone marrow cell gene expression and tissue construct assembly using octacalcium phosphate microscaffolds. R.M. Shelton, Y. Liu, P.R. Cooper, U. Gbureck, M.J. German and J.E. Barralet. Biomaterials, 27, (14), 2874-2881, 2006.

How good is research at University of Birmingham in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 15.90

Research output data provided by the Research Excellence Framework (REF)

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