The role of extracellular mechanics in skin tissue engineering and ageing (Durham, iCASE award)
Mechano-sensing and biomechanics are key cellular attributes that govern tissue formation and homeostasis. How cells sense their surroundings and how ageing-associated ECM geometry and stiffness changes contribute to skin atrophy is poorly understood. Our unpublished findings show that nuclear proteins (i.e. LINC complex) and members of the Hippo pathway, which are involved in biomechanics, play key roles in epidermal stratification, fibroblast activation and 3D organization both in vitro and in vivo. Therefore, the aim of the project is to modulate extracellular and cellular mechanics in order to develop novel in vitro 3D models that mimic young and aged skin. The major attraction of the project is that it is multifaceted involving both industrial and academic input. You will work with experts that are leaders in skin tissue engineering, ageing, and biomechanics and apply a wide range of cell biological, tissue engineering and advanced imaging techniques in order to realize the aims of the project.
For further information see the website: https://www.dur.ac.uk/biosciences/
To apply: Please submit a full CV and covering letter directly to [email protected]
This is a 4 year BBSRC iCASE studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£14,057 for 2015-16). The PhD will start in September 2016. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. There are 2 stages to the application process.
Lu W., Schneider M., Neumann S., Jaeger V.M., Taranum S., Munck, M., Cartwright, S., Richardson C., Carthew, J., Noh, W., Goldberg M., Noegel A., and Karakesisoglou I. (2012) Nesprin interchain associations control nuclear size. Cell. Mol. Life Sci. 69: 3493-3509. Citations: 20