This project aims to provide insight into the molecular mechanisms that enable healthy ageing. Small heat shock proteins have an evolutionarily conserved role in promoting a long and healthy life in simple model organisms, but how they do this is unclear. The student taking this project would take an unbiased approach to addressing this question, by creating and analysing thousands of independent yeast mutant strains covering the entire genome. The student would then use computational approaches to predict the functionally important cellular proteins, pathways and processes that sHSPs affect and then test these predictions in small scale functional genetic experiments to determine the effects on ageing in yeast and nematode worms. This project will provide training in modern genetic and genomic techniques using two key model organisms and may provide novel insights into the conserved functions of sHSPs in promoting healthy ageing.
For further information see the website: https://www.liverpool.ac.uk/translational-medicine/
Please submit a full CV and covering letter directly to [email protected]
This is a 4 year BBSRC studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£14,057 for 2015-16). The PhD will start in September 2016. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. There are 2 stages to the application process.
Herbert, A.P., Riesen, M., Bloxam, L., Kosmidou, E., Wareing, B.M., Johnson, J.R., Phelan, M.M., Pennington, S.R., Lian, L.Y. and Morgan, A. (2012) NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast. PLoS One. 7, e41975