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Role of Neurospora heat shock transcription factors in temperature sensing and development

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  • Full or part time
    Dr Crosthwaite
    Prof Griffiths-Jones
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

The filamentous fungus Neurospora crassa is a well-known model eukaryote used for studying numerous phenomena including; gene silencing, light signal transduction and the circadian clock. The Neurospora genome is fully sequenced and contains almost 10 000 genes many of which encode proteins of unknown function. Investigations into the role of these proteins of unknown function will not only throw light on Neurospora growth and survival strategies but also inform studies on other industrially important fungi, cultivated strains, and plant and animal pathogens.

We are interested in the role of two genes encoding proteins similar to heat shock transcription factors. We found that hsf1 is an essential gene and that hsf2 is required for asexual sporulation (Thompson et al., 2008). The aim of this project is to identify targets of HSF1 and HSF2 and determine their importance for the organisms’ development and its ability to respond to temperature change.

Funding Notes

This project has a Band 2 fee. Details of our different fee bands can be found on our website. For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website. Informal enquiries may be made directly to the primary supervisor.

References

Thompson S, Croft NJ, Sotiriou A, Piggins HD, Crosthwaite SK. (2008) Neurospora crassa heat shock factor-1 is an essential gene; a second heat shock factor-like gene, hsf2, is required for asexual spore formation. Eukaryot. Cell 7, 1573-1581.

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