Virulence factors of human and bird Trichomonad parasites targeting host glycoproteins: integrating evolutionary biology, comparative genomics, biochemistry and cell biology (Newcastle)
This project represents a unique opportunity to gain multidisciplinary skills integrating ‘omics (comparative and evolutionary genomics and transcriptomics) with functional characterisations (biochemistry and molecular cell biology) of candidate virulence factors of important Trichomonas parasites with worldwide distribution affecting human and avian populations. It is increasingly recognised that successful control of zoonotic pathogens requires joint veterinary and medical efforts; hence this brands Trichomonas species as an important emerging model system to study pathogens with zoonotic origins. The multidisciplinary nature of the project will ensure that the PhD candidate is expose to a combination of important topical and transferable research skills. These skills with be gained in the context of three highly active research laboratories with strong complementary and overlapping research interests active in the studies on human-microbe interactions exploiting large ‘omics datasets leading to targeted functional investigations that aim at eventually developing new prophylactic and therapeutic strategies to combat infections.
For further information see the website: http://www.ncl.ac.uk/camb/
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This is a 4 year BBSRC studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£14,057 for 2015-16). The PhD will start in September 2016. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. There are 2 stages to the application process.
Carlton JM, Hirt RP, et al. and Johnson, PJ (2007). Draft genome sequence of the sexually-transmitted pathogen Trichomonas vaginalis. Science, 315: 207-212.