This project is no longer listed in the FindAPhD
database and may not be available.
This project has a Band 2 fee. Details of our different fee bands can be found on our website. For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website. Informal enquiries may be made directly to the primary supervisor.
Lopez-Castejon G, Luheshi NM, Compan V, High S, Whitehead RC, Flitsch SL, Kirov A, Prudovsky I, Swanton E, Brough D, Deubiquitinases regulate the activity of caspase-1 and IL-1β secretion via assembly of the inflammasome Journal of Biological Chemistry, 2013, 288:2721-2733
Savage CD, Lopez-Castejon G, Denes A, Brough D, NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury Frontiers in Immunology, 2012, 3:288.
Brough D, Tyrrell PJ, Allan SM, The Regulation of Interleukin-1 in Acute Brain Injury Trends in Pharmacological Sciences, 2011, 32:617-622.