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Candida auris: An Emerging Fungal Pathogen

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  • Full or part time
    Dr MacCallum
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Candida auris is an opportunistic fungal pathogen, which has been linked with bloodstream infections in India and South Korea. Unusually, a recent outbreak has occurred in a London Hospital Intensive Care Unit (ICU) where twenty patients all developed infections caused by Candida auris. Microsatellite typing of these strains, carried out in Aberdeen, suggests they may all be the same strain type or closely related. This PhD project will design a Multi-Locus Typing Scheme (MLST) to type and compare the twenty strains obtained to date, as well as characterising the strains to determine which phenotypic characteristics have allowed this to emerge as a pathogen in the ICU. Comparative virulence of this species relative to Candida albicans and other pathogenic fungi will be determined in range of in vitro and in vivo models.

Funding Notes

This project is part of a competition funded by the Elphinstone Scholarship Scheme. Successful applicants will be awarded full tuition fees (UK/EU/International) for the duration of a three year PhD programme. Please note that this award does not include a stipend.

This award is available to high-achieving students. Candidates should have (or expect to achieve) a minimum of a First Class Honours degree in a relevant subject. Applicants with a minimum of a 2.1 Honours degree may be considered provided they have a Distinction at Masters level.

References

Chowhary et al (2013) Emerging Infectious Diseases 9; http://wwwnc.cdc.gov/eid/article/19/10/pdfs/13-0393.pdf; Odds& Jacobsen (2008) Eukaryotic Cell 7: 1075–1084, http://ec.asm.org/content/7/7/1075.full.pdf+html

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