Versatile chiral building blocks by catalytic C-H and C-C activation
Dr A Sergeev
Dr K Luzyanin
No more applications being accepted
Funded PhD Project (UK Students Only)
Enthusiastic graduates are invited to apply for a 42-month PhD studentship available in the research groups of Dr Alexey Sergeev (supervisor) and Dr Konstantin Luzyanin (co-supervisor) at the Department of Chemistry, University of Liverpool, UK. Start date: October 1, 2016. The studentship covers tuition fees and the initial stipend of £14142 with rises anticipated in future years.
This PhD program will fill the gap in existing methods for the synthesis of chiral biaryl compounds, one of the most versatile and important class of chiral building blocks in organic synthesis and catalysis. The program will focus on the design of a short synthetic route to these compounds through activation of strong C-H and C-C bonds in readily available aromatic starting materials by well-defined transition metal catalysts. In addition to the development of novel synthetic methods, the program will focus on mechanistic investigations that would provide better fundamental understanding of underpinning catalytic C-H and C-C functionalizations and would lead to the design of more active and stable catalysts for these processes. The envisioned methodology will be applied for the concise synthesis of natural compounds of pharmacological interest and key chiral auxiliaries for transition metal and organocatalysis.
During work on the project, the candidate will receive extensive training in organic and organometallic synthesis using Schlenk and glovebox techniques and will have hands-on experience in application of modern analytical methods (NMR, MS, GC/MS and HPLC). The knowledge and skills developed will provide the candidate with a solid foundation for his/her future academic or industrial career in organic chemistry and catalysis.
We are looking for creative and highly motivated graduates with Masters degree in chemistry (First or Upper Second class). Excellent experimental skills and knowledge of organic chemistry are required; a background in organometallic chemistry and catalysis would be an advantage.
Applicants should send a cover letter outlining motivation and suitability for this project, and a full CV with the names of two referees to Dr Alexey Sergeev ([Email Address Removed]) and Dr Konstantin Luzyanin ([Email Address Removed]).
Keywords: catalysis, organic synthesis, asymmetric synthesis, C-H activation, C-C activation
Due to funding restrictions this fully funded position is open for UK residents only. For more details, please see refer to the EPSRC website: http://www.epsrc.ac.uk/skills/students/help/eligibility/.