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Cellular membrane traffic in the congenital demyelinating disorder Charcot Marie Tooth type 4

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  • Full or part time
    Dr L Swan
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

A funded PhD position is available working on a project to identify the key membrane trafficking events in a network of five functionally related genes which all cause the debilitating congenital disorder, Charcot Marie Tooth Type 4 neuropathy. These genes all converge to regulate the membrane lipid phosphatidylinositol (3,5) bis phosphate (PI(3,5)P2), a critical marker and regulator of membrane trafficking decisions in the cell. The successful candidate will use a combination of differential mass spectrometry, cell biology, biochemical assays and light microscopy to identify key organelles and protein-protein interactions in models of peripheral myelination in cell culture.

Application enquiries to Laura Swan ([email protected]).

Funding Notes

3 year studentship, including stipend at RCUK rates and Home/EU tuition fees. Students from outside EU would be expected to fund tuition in excess of this amount.
You should have, or expect to hold a first or upper second class honours degree or equivalent in a relevant discipline. Laboratory experience is desirable but not essential. English Language Requirement for non-English speakers is an IELTS score of 6.5 with no band score lower than 5.5.
To apply please send a cover letter summarising past experience, motivation and interest in the project & a CV including details of three referees to [email protected]


1. Recognition of the F&H motif by the Lowe syndrome protein OCRL. Pirruccello M, Swan LE, Folta-Stogniew E, De Camilli P. Nat Struct Mol Biol. 2011 Jun 12;18(7):789-95. doi: 10.1038/nsmb.2071.
2. Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene.
Lenk GM, Frei CM, Miller AC, Wallen RC, Mironova YA, Giger RJ, Meisler MH. Hum Mol Genet. 2016 Jan 15;25(2):340-7. doi: 10.1093/hmg/ddv480.
3. Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1.
Swan LE, Tomasini L, Pirruccello M, Lunardi J, De Camilli P. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3511-6. doi: 10.1073/pnas.0914658107.
4. Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, Lucast L, Khoo C, Zhang X, Li L, Abrams CS, Sokol SY, Wu D. Science. 2008 Sep 5;321(5894):1350-3. doi: 10.1126/science.1160741.

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