• University of Pennsylvania Featured PhD Programmes
  • University of Tasmania Featured PhD Programmes
  • FindA University Ltd Featured PhD Programmes
  • Staffordshire University Featured PhD Programmes
  • University of Cambridge Featured PhD Programmes
  • Aberdeen University Featured PhD Programmes
University of Liverpool Featured PhD Programmes
University of Bristol Featured PhD Programmes
Norwich Research Park Featured PhD Programmes
Coventry University Featured PhD Programmes
University of Tasmania Featured PhD Programmes

Cellular membrane traffic in the congenital demyelinating disorder Charcot Marie Tooth type 4

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Dr Swan
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

A funded PhD position is available working on a project to identify the key membrane trafficking events in a network of five functionally related genes which all cause the debilitating congenital disorder, Charcot Marie Tooth Type 4 neuropathy. These genes all converge to regulate the membrane lipid phosphatidylinositol (3,5) bis phosphate (PI(3,5)P2), a critical marker and regulator of membrane trafficking decisions in the cell. The successful candidate will use a combination of differential mass spectrometry, cell biology, biochemical assays and light microscopy to identify key organelles and protein-protein interactions in models of peripheral myelination in cell culture.

Application enquiries to Laura Swan ([email protected]).

Funding Notes

3 year studentship, including stipend at RCUK rates and Home/EU tuition fees. Students from outside EU would be expected to fund tuition in excess of this amount.
You should have, or expect to hold a first or upper second class honours degree or equivalent in a relevant discipline. Laboratory experience is desirable but not essential. English Language Requirement for non-English speakers is an IELTS score of 6.5 with no band score lower than 5.5.
To apply please send a cover letter summarising past experience, motivation and interest in the project & a CV including details of three referees to [email protected]

References

1. Recognition of the F&H motif by the Lowe syndrome protein OCRL. Pirruccello M, Swan LE, Folta-Stogniew E, De Camilli P. Nat Struct Mol Biol. 2011 Jun 12;18(7):789-95. doi: 10.1038/nsmb.2071.
2. Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene.
Lenk GM, Frei CM, Miller AC, Wallen RC, Mironova YA, Giger RJ, Meisler MH. Hum Mol Genet. 2016 Jan 15;25(2):340-7. doi: 10.1093/hmg/ddv480.
3. Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1.
Swan LE, Tomasini L, Pirruccello M, Lunardi J, De Camilli P. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3511-6. doi: 10.1073/pnas.0914658107.
4. Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Pan W, Choi SC, Wang H, Qin Y, Volpicelli-Daley L, Swan L, Lucast L, Khoo C, Zhang X, Li L, Abrams CS, Sokol SY, Wu D. Science. 2008 Sep 5;321(5894):1350-3. doi: 10.1126/science.1160741.

Share this page:

Cookie Policy    X