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Free radical mechanism of ferritins

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  • Full or part time
    Dr Svistunenko
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

A PhD studentship will be available at the Biomedical EPR Facility to study ferritins – ubiquitous enzymes that accumulate iron for cell’s needs and handle iron’s intrinsic toxicity. Ferritins from different organisms exhibit structural differences and, consequently, demonstrate rather different mechanisms of iron acquisition. We recently demonstrated [1], that iron acquisition in E. coli ferritin is associated with free radical formation on the enzyme. The mechanism of this free radical driven iron mineralisation, in ferritins from different organisms, is in the focus of the PhD studentship programme. Successful output of the programme is expected to be accurate kinetic characterisation, by several spectroscopic methods, of the mineralisation process which would allow creation of kinetic models. The candidate is expected to be fluent in basic biochemistry, to be familiar with several spectroscopic methods including fast kinetic techniques. Knowledge of and experience in EPR spectroscopy will be considered advantageous. Successful candidate will benefit from learning several wet lab and computational protocols exercised in the friendly and diverse research environment of the School as well as from collaborative contacts with the University of East Anglia which has very a strong record of ferritins studies. The candidates are expected to speak fluent English.

Funding Notes

Entry requirements and application procedures
Applications should be submitted electronically by Tuesday 29 March 2016 see here for details https://www.essex.ac.uk/pgapply/enter.aspx

Additional questions and queries about the studentship can be addressed to Dr Dima Svistunenko at svist (@essex.ac.uk)

The target start date for this 3-year, fully-funded PhD studentship is 6th October 2016. This scholarship will be to the value of £12,500 per annum plus UK tuition fees.

References

1. Bradley, J. M., Svistunenko, D. A., Lawson, T. L., Hemmings, A. M., Moore, G. R. and Le Brun, N. E. (2015) Three aromatic residues are required for electron transfer during iron mineralization in bacterioferritin. Angew. Chem. Int. Ed. 54, 14763 –14767

How good is research at University of Essex in Biological Sciences?

FTE Category A staff submitted: 23.00

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