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database and may not be available.
The 3 year MRC funded studentships are open to outstanding UK science graduates wishing to pursue a career in Reproductive Health. The studentship will cover fees at the UK/EU rate and a minimum stipend as directed by the MRC.
This research project will be in direct competition with 7 other projects currently on offer at the MRC-CRH. Usually the project with the best applicant/s will be awarded the funding. The funding is available to UK graduates who can demonstrate ordinary residence in the UK as defined at through the link below.
1. E. Greaves, F. L. Cousins, A. Murray, A. Esnal-Zufiaurre, A. Fassbender, A. W. Horne, P. T. Saunders, A novel mouse model of endometriosis mimics human phenotype and reveals insights into the inflammatory contribution of shed endometrium. Am J Pathol 184, 1930-1939 (2014).
2. L. C. Davies, S. J. Jenkins, J. E. Allen, P. R. Taylor, Tissue-resident macrophages. Nat Immunol 14, 986-995 (2013).
3. E. L. Gautier, T. Shay, J. Miller, M. Greter, C. Jakubzick, S. Ivanov, J. Helft, A. Chow, K. G. Elpek, S. Gordonov, A. R. Mazloom, A. Ma'ayan, W. J. Chua, T. H. Hansen, S. J. Turley, M. Merad, G. J. Randolph, Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immunol 13, 1118-1128 (2012).
4. S. Gordon, P. R. Taylor, Monocyte and macrophage heterogeneity. Nat Rev Immunol 5, 953-964 (2005).
5. X. Cao, D. Yang, M. Song, A. Murphy, S. Parthasarathy, The presence of endometrial cells in the peritoneal cavity enhances monocyte recruitment and induces inflammatory cytokines in mice: implications for endometriosis. Fertil Steril 82 Suppl 3, 999-1007 (2004).
6. A. Capobianco, A. Monno, L. Cottone, M. A. Venneri, D. Biziato, F. Di Puppo, S. Ferrari, M. De Palma, A. A. Manfredi, P. Rovere-Querini, Proangiogenic Tie2(+) macrophages infiltrate human and murine endometriotic lesions and dictate their growth in a mouse model of the disease. Am J Pathol 179, 2651-2659 (2011).
7. A. Capobianco, P. Rovere-Querini, Endometriosis, a disease of the macrophage. Front Immunol 4, 9 (2013).
8. C. Schulz, E. Gomez Perdiguero, L. Chorro, H. Szabo-Rogers, N. Cagnard, K. Kierdorf, M. Prinz, B. Wu, S. E. Jacobsen, J. W. Pollard, J. Frampton, K. J. Liu, F. Geissmann, A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336, 86-90 (2012).
9. M. T. Beste, N. Pfaffle-Doyle, E. A. Prentice, S. N. Morris, D. A. Lauffenburger, K. B. Isaacson, L. G. Griffith, Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation. Science translational medicine 6, 222ra216 (2014).
FTE Category A staff submitted: 206.93
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