• University of Cambridge Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of Glasgow Featured PhD Programmes
  • University of Leeds Featured PhD Programmes
  • University of Mannheim Featured PhD Programmes
  • Carlos III Health Institute Featured PhD Programmes
  • London School of Economics and Political Science Featured PhD Programmes
  • University of Bristol Featured PhD Programmes
Wellcome Trust Featured PhD Programmes
University of Oxford Featured PhD Programmes
University of Glasgow Featured PhD Programmes
King’s College London Featured PhD Programmes
University of Manchester Featured PhD Programmes

Genetic contributions to speech and language disorders

This project is no longer listed in the FindAPhD
database and may not be available.

Click here to search the FindAPhD database
for PhD studentship opportunities
  • Full or part time
    Dr Newbury
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Competitive three year full time studentship in the Department of Biological and Medical Sciences

Research Title : Genetic contributions to speech and language disorders

Main supervisor Dr Dianne Newbury


Eligibility:Only open to UK/EU applicants (who must be permanently resident in UK/EU)


Start date: 19th September 2016

Bursary: £14057 pa for academic year 2016/17 & fees

Closing date: 21st February 2016

Applicants should be of the highest quality and capable of submitting a PhD thesis within 3 years. Requirement a good Honours degree (2.1 or equivalent).

EU applicants must have a valid IELTS Academic test certificate minimum score level 6 in each of the four areas of reading, writing, listening and speaking with overall minimum score 7.0 issued since the 23rd April 2015 by an approved test centre please see web site below. Or an undergraduate degree awarded by a recognised UK university within the last two years.

https://www.gov.uk/government/publications/guidance-on-applying-for-uk-visa-approved-english-language-tests

Project summary

Auditory Processing Disorder (APD) is a deficit in the perception of speech sounds, especially in background noise, despite normal hearing and auditory function (Moore et al. 2013). Individuals affected by APD often require the repetition of information and struggle to interact in noisy group activities which impacts upon school achievement. Effective auditory processing is important for language acquisition and APD is often associated with speech and language disorders (SLD), developmental and learning difficulties (Moore et al. 2013). Nonetheless, it is still a matter of debate whether APD represents a sub-clinical hearing deficit, a processing difficulty within the central auditory pathway or a symptom of another disorder (e.g. attention).

We have recently completed exome sequencing and SNP genotyping of a family affected by APD and have identified coding variants in several genes that are related to hearing and central auditory processes. The primary aim of this project is to evaluate the relevance of these changes in relation to auditory processing. The project will involve bioinformatic analyses of existing datasets within this family and other families affected by auditory processing disorder, validation of candidate changes using lab techniques such as sequencing and quantitative PCR and investigation of candidate pathways using cellular models. This project provides opportunities for training in genomic and functional genetic assays in the laboratory. These will include the use of quantitative PCR, tissue culture and immunochemistry techniques, DNA sequence analysis and the use of associated bioinformatic packages.

This work will provide an essential link between identified changes in the genetic sequence and the functionality of genes. Evidence of altered gene function would not only provide further support for the observed association but would also indicate a mechanism by which auditory processing disorder may occur. This is an important step in the development of future studies and will further understanding regarding the mechanism of pathogenesis in language disorders (Newbury et al 2014).


As part of your training you will be required to assist in demonstrating on undergraduate practicals during semesters without further remuneration.


Further information on the project please contact Dr Dianne Newbury
e-mail address [email protected]

How to apply

Please complete the Application Form, which you can download from

http://www.hls.brookes.ac.uk/images/research/phd-studentship-application-form-jan-14.doc


With your application please enclose a CV and scanned copy of your degree certificates and transcripts and letter from awarding body plus two signed academic references. Additionally if appropriate a valid IELTS Academic test score certificate.


Please carefully note that applications only accepted by e-mail to the following address:
[email protected]




YOU MUST NOT SENT ANY QUERIES, APPLICATION, CV, OR OTHER DOCUMENTATION VIA FINDAPHD

Funding Notes

Start date: 19th September 2016

Bursary: £14057 pa for academic year 2016/17 & fees

Closing date: 21st February 2016

Requirement a good Honours degree minimum 2.1 from a UK university or acceptable equivalent from a recognised university

EU applicants must have a valid IELTS Academic test certificate minimum score level 6 in each of the four areas of reading, writing, listening and speaking with overall minimum score 7.0 issued since the 23rd April 2015 by an approved test centre please see web site below. Or an undergraduate degree awarded by a recognised UK university within the last two years.

https://www.gov.uk/government/publications/guidance-on-applying-for-uk-visa-approved-english-language-tests


References

Newbury DF, Monaco AP, Paracchini S. Reading and language disorders: the importance of both quantity and quality. Genes. 2014 5:285-309.
Moore, Rosen, Bamiou, Campbell & Sirimanna. Evolving concepts of developmental auditory processing disorder (APD): a British Society of Audiology APD special interest group 'white paper'. Int J Audiol 2013 52: 3-13.


How good is research at Oxford Brookes University in Biological Sciences?

FTE Category A staff submitted: 25.60

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities
Share this page:

Cookie Policy    X