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Computer modelling and experimental studies on the control of glycine homeostasis in the human central nervous system

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  • Full or part time
    Dr Poolman
  • Application Deadline
    No more applications being accepted
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Three year full time studentship in the Department of Biological and Medical Sciences


Research title : Computer modelling and experimental studies on the control of glycine homeostasis in the human central nervous system.


Main Supervisor Dr Mark Poolman



Eligibility: Only open to UK/EU applicants (who must be permanently resident in UK/EU)


Start date: 4th April 2016

Bursary: £14057 pa (pro rata as April start) for academic year 2015/16 & fees

Closing date: 28th February 2016

Applicants should be of the highest quality and capable of submitting a PhD thesis within 3 years. Requirement a good Honours degree (2.1 or equivalent).

EU applicants must have a valid IELTS Academic test certificate minimum score level 6 in each of the four areas of reading, writing, listening and speaking with overall minimum score 7.0 issued since the 23rd April 2015 by an approved test centre please see web site below. Or an undergraduate degree awarded by a recognised UK university within the last two years.

https://www.gov.uk/government/publications/guidance-on-applying-for-uk-visa-approved-english-language-tests


Project summary

The project involves a systems biology approach using computer modelling and experimental approaches to examine the role and control of glycine homeostasis in the Human brain where glycine is an important inhibitory neurotransmitter.

The synaptic action of glycine is terminated by glycine transporters present in the plasma membrane of glial cells or pre-synaptic terminals, respectively, and glycine is synthesised from serine by the enzyme serine hydroxymethyltransferase. Understanding how the nervous system controls glycine homeostasis and the potential effects of this on glycine receptors may lead to new targets for therapeutic of pathological alterations in synaptic function.

The appointed individual will gain experience and expertise in advanced computer modelling approaches as well as in vitro receptor have the opportunity to regularly disseminate her/his work at national and international meetings and to participate in outreach activities such as Science Festivals and talks in schools.

Further details can be found at: http://mudshark.brookes.ac.uk/Situations%20Vacant

Any queries please contact Dr Mark Poolman e-mail [email protected]

How to apply

Please complete the Application Form, which you can download from

http://www.hls.brookes.ac.uk/images/research/phd-studentship-application-form-jan-14.doc


With your application you should enclose a CV plus scanned copy of your degree certificates and transcripts and letter from awarding body. You must also enclose two signed academic references with your application. Additionally if appropriate a valid IELTS Academic test score certificate. EU applicants must include a SKYPE address.

Please carefully note that applications plus supporting documentation will only be accepted by e-mail
to the following address: [email protected]



YOU MUST NOT SEND ANY QUERIES, APPLICATION, CV OR OTHER DOCUMENTATION VIA FINDAPHD

Funding Notes

Start date: 4th April 2016

Bursary: £14057 pa (pro rata as April start) for academic year 2015/16 & fees

Closing date: 28th February 2016

Required Honours degree minimum 2.1 or higher from a UK university or acceptable equivalent qualification from a recognised university.

EU applicants requirement IELTS Academic test certificate minimum score level 6 in each of the four areas of reading, writing, listening and speaking with overall minimum score 7.0 issued since the 23rd April 2015 from approved test centre see web site below. Or undergraduate degree awarded by a recognised UK university within the last two years.

https://www.gov.uk/government/publications/guidance-on-applying-for-uk-visa-approved-english-language-tests

How good is research at Oxford Brookes University in Biological Sciences?

FTE Category A staff submitted: 25.60

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities
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