Dr J Rodriguez
Applications accepted all year round
About the Project
Interested in the generation of cellular diversity? Most animal cells are polarized; they show functional differences across the cell. Cell polarity is essential for the generation of asymmetric divisions, cellular movements and for cells to organize into complex structures such as organs. Dysregulation of cell polarity can cause developmental disorders, including different types of cancer (NatRevCancer_2012_vol.12(1)_pp.23-38). This PhD will explore how cell polarity arises and is controlled.
The cellular cytoskeleton is involved in the asymmetric distribution of proteins that orchestrate cell polarity. How the cytoskeleton and in particular microtubules (MT) regulate polarity proteins remains elusive (Genes&Development_2007_vol.21(5)_pp.483-96). To address this, we have identified the most comprehensive network of polarity regulators (NatCellBiol_2012_vol.15(1)_pp.103-12). This network currently informs our design of genetic screens in C. elegans, which are successfully identifying novel MT-dependent polarity regulators in asymmetric division. The student will join this screening effort and will characterise our findings in mammalian cells using state-of-the-art genetics, biochemical, molecular, live cell micromanipulation and imaging techniques to determine the polarity role of the identified genes.
Cell polarity and microtubule regulation are at the heart of multiple developmental biology processes. Hence, it is expected that this work will provide insight into many human disorders.
We will support the scientific growth of the successful student in an inter-disciplinary research environment within the Cell Division Biology Research group (http://research.ncl.ac.uk/celldivisionbiology/) and in world-class facilities at the Institute for Cell and Molecular Biosciences (http://www.ncl.ac.uk/camb/facilities/).
Eligibility Criteria
You must have or expect a 2:1 Honours degree in a biological, biochemistry or realted degree. A further qualification (MSc or Mres) is advantageous. We are looking for highly motivated students with interest in Cell and Developmental Biology.
The award is available to UK/EU and international applicants. If English is not your first language, you must have IELTS 6.5, or equivalent.
How to apply
You must apply through the University’s online postgraduate application system - http://www.ncl.ac.uk/postgraduate/apply/. To do this please ‘Create a new account’.
Only mandatory fields need to be completed. However, you will need to include the following information:
• insert the programme code 8300F in the programme of study section
• select ‘PhD in the Faculty of Medical Sciences – Cell and Molecular Biosciences’ as the programme of study
• insert the studentship code 11MREA in the studentship/partnership reference field
• attach a covering letter and CV. The covering letter must state the title of the studentship and supervisor, quote the studentship reference code 11MREA and state how your interests and experience relate to the project
• attach degree transcripts and certificates and, if English is not your first language, a copy of your English language qualifications
Funding Notes
Sponsor: Research Excellence Academy, Faculty of Medical Sciences, Newcastle University
Value of award: 100% of UK/EU tuition fees paid and annual living expenses of £14,296 (full award). International candidates will be required to make up the difference between the UK/EU fees and international fees.