About the Project
Project Background
Polymeric nanoparticle systems represent cutting edge technology in the fields of biomedical and pharmaceutical sciences. The potential to harness their unique and tuneable physiochemical properties affords them the ability to be utilised in a wide range of bio-applications, encompassing themes of biomaterials, nanotechnology, nanomedicine, drug delivery, cell biology, pharmaceutics, microbiology, and advanced microscopy.
Your project will build upon the foundations of prior art, in order to research, design, develop, characterise, and evaluate novel polymeric nanoparticles (PNP).
http://blogs.brighton.ac.uk/jonathansalvage/
Applications are invited for polymeric nanoparticle themed PhD projects within the topics of:
Anticancer – Development of PNP based nanomedicine systems for the delivery of anti-cancer drugs, to improve therapeutic efficacy. PNP systems offer the potential to improve effectiveness of delivery in terms of increased loading, targeting, and controlled release at the site of action.
Antibiotic – Development of PNP based systems for the delivery of antimicrobial agents to infected cells to enhance therapeutic efficacy. PNP systems offer the potential to improve treatment of intracellular microbial infection derived diseases.
MRI – Development of PNP based magnetic resonance imaging (MRI) contrast agent delivery systems, aiming to improve efficacy, targeting, and imaging capabilities.
Bioimaging – Development of PNP based fluorescent systems for bio-imaging and tracking of live cells, aiming to improve efficacy of the fluorescent probe, whilst maintaining cell viability.
Programme of work
Your project will be an integrated programme of work providing a clear and logical path of progression, and may involve material synthesis, characterisation, and evaluation, undertaken in our state-of-the-art research laboratories.
Facilities including nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), dynamic light scattering (DLS), electron microscopy (SEM, STEM), atomic force microscopy (AFM), energy dispersive x-ray spectroscopy (EDS), high performance liquid chromatography (HPLC), surface optical contact angle (OCA) analysis, UV spectroscopy, confocal laser scanning microscopy (CLSM), flow cytometry, in-vitro cell culture, and microbiology are available.
Projects are multi-disciplinary specifically to produce highly capable graduates, and you will join and work within an international, and multi-skilled, research environment. You will have the opportunity to develop a comprehensive knowledge of in-demand research abilities and expertise, together with technical and academic adaptability and determination, in order to allow you to compete effectively in the post-doctoral domain.
Funding Notes
For self funding students.
Project scope will be dependent on level of self-funding available.
Applicants should hold a BSc (minimum 2:2 (Hons)) in Pharmaceutical Sciences, Chemistry, Biology, or a closely related discipline.
Applicants whose first language is not English, must have successfully completed a Secure English language Test (SELT) in the last two years. Applicants who have obtained or are studying for a UK degree may apply without a SELT. However, the university may request a SELT is taken as part of any award made.
English language IELTS requirements are a 6.5 overall and minimum 6.0 for writing
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