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Designing of novel biosensors using synthetic biology approaches

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Infectious diseases are still a major cause of death, disability and social and economic upheaval accounting for more than 11.9 million deaths a year worldwide. Current efforts concentrate on the development of novel antimicrobial and therapeutic strategies. However, early interventions based on state-of-the-art diagnostic strategies and novel treatments that will accelerate the detection and management of bacterial infections is paramount to substantially reduce the impact of infectious diseases. Many bacterial pathogens produce signature signal molecules to control their virulence by a process known as quorum sensing (QS). Our laboratory has years of expertise studying these signalling processes and in designing biosensors for their detection. However, these biosensors are usually not sensitive enough to detect the very low levels of these molecules in human samples, especially during the early stages of infection. We have recently been using synthetic biology strategies with the aid of molecular biology and computational modelling approaches to design sophisticated synthetic circuits which can sense with increased sensibility the signature molecules and amplify the responses to low signal levels. These strategies are leading to many applications, some of which will have clinical outcomes. The aim of this project is to recycle some of these engineered circuits for the design of highly sensitive biosensors which can be used to detect early stages of infection through the detection of QS molecules and trigger a genetically-controlled biological response which will additionally result in a reactive first line of defence against the invading pathogen. The project will provide extensive training in molecular biology, synthetic biology, computer modelling, microscopy and analytical biochemistry techniques.

Funding Notes

Home applicants should contact the supervisor to determine the current funding status for this project. EU applicants should visit the Graduate School webpages for information on specific EU scholarships View Website. International applicants should visit our International Research Scholarships page for information regarding fees and funding at the University View Website.

Related Subjects

How good is research at University of Nottingham in Biological Sciences?

FTE Category A staff submitted: 90.86

Research output data provided by the Research Excellence Framework (REF)

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