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The role of cellular metabolism in blood flow regulation using novel imaging approaches

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Our research is interdisciplinary and translational, combining magnetic resonance (MR) imaging and spectroscopy methods, immunohistochemistry and molecular biology to study cellular metabolism and blood flow regulation in health and disease. We are currently involved in the development of a cutting-edge metabolic imaging method- called Dynamic Nuclear Polarisation 13C MR spectroscopy- to investigate metabolic changes associated with brain and musculoskeletal function. This novel approach could provide platform for diagnosis and treatment of age-related diseases in the clinic.

In this project, we aim to study the metabolism of brain perivascular cells (e.g. astrocytes and pericytes) in response to disease and determine how this alters the control of blood flow. To this end, we will use a combination of cell culture, immunostaining, and metabolic measurements to identify and assess metabolic pathways that are associated with the regulation of blood flow.
This work will form the basis of future experiments that aim to study metabolism in real time and non-invasively using Dynamic Nuclear Polarisation 13C MR spectroscopy in both animal models and human subjects.

Funding Notes

Home applicants should contact the supervisor to determine the current funding status for this project. EU applicants should visit the Graduate School webpages for information on specific EU scholarships View Website. International applicants should visit our International Research Scholarships page for information regarding fees and funding at the University View Website.

How good is research at University of Nottingham in Biological Sciences?

FTE Category A staff submitted: 90.86

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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