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  Single-molecule approach to understand nucleotide excision repair pathway in bacteria.


   Department of Biochemistry

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  Dr Pawel Zawadzki  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

Newly funded laboratory „Single-molecule biophysics of DNA repair“ opens position for a PhD student available from 1st November 2016. The position is fully funded for 3 years (scholarship of 850 euro/month) with the possibility of extension for additional year. The project is focusing on understanding of DNA repair, both in vitro and in vivo, of nucleotide excision repair pathway in bacteria. Methodology is mostly based on cutting-edge single-molecule technologies including single-molecule FRET and super-resolution microscopy. The project is the collaboration between laboratories in Poznan University (Department of Physics), International Institute of Molecular and Cellular Biology in Warsaw and Oxford University (Department of Biochemistry). Majority of time applicant will spend in Poznan (Poland), however frequent visits to Warsaw and Oxford (UK) are planned.
Master of Science in molecular biology, biochemistry, cell biology or biophysics is required and any experience in single-molecule technologies would be an advantage.
If interested, please contact directly (CV and covering letter) the head of the project: dr Pawel Zawadzki ([Email Address Removed]).

Applications will be reviewed by the end of September and the interviews with selected candidates held shortly after.

References

Literature:
Stracy M., Jaciuk M., Uphoff S., Kapanidis A., Nowotny M., Sherratt DJ., Zawadzki P. (2016) UvrA initiates nucleotide excision repair by recruiting UvrB from solution to DNA lesions. (Nature Communications)

Zawadzki P., Stracy M., Ginda K., Lesterlin C., Zawadzka K., Kapanidis A., and Sherratt DJ. (2015) The localization and action of topoisomerase IV in Escherichia coli chromosome segregation is coordinated by the SMC complex, MukBEF. (Cell Reports,13:2587-96)

Zawadzki P., May P., Pinkney J.N.M., Baker R., Kapanidis N.A., Sherratt J.D., Arciszewska K.L. (2013) Conformational transitions during FtsK translocase activation of individual XerCD-dif recombination complexes. PNAS. 110,17302-7.

 About the Project