The interaction of dietary micronutrients with genetic factors in shaping obesity-related phenotypes in adults and children

We are generating a unique multigenerational set of genotypic data from over 1500 parents and their children as part of the’ Growing Up in Australia’ study with which to dissect the genetic architecture of obesity-related phenotypes in both generations. This genetic ‘risk profile’ will form in important platform on which to investigate gene:environment interactions. In parallel, we are implementing a platform for the analysis of targeted lipo-soluble vitamers and metabolites in the methionine cycle. Each of these factors has potential to interact with genetic variation to impact obesity related outcomes such as BMI and adiposity.

Aim:

This PhD will explore how micronutrient profiles influence underlying genetic risk for a range of obesity-related phenotypes in adults and their children.

Description:

We will develop and ascertain the utility of a genetic-nutrition-based predictor (risk score) of obesity-related phenotypes across the first decade of life and across mid-life. This offers tremendous potential for a precision approach at two life stages critical to subsequent health, targeting those most likely to benefit from intervention in the longer term.

The PhD candidate will be contributing to the data derivation and management of the relevant CheckPoint and LSAC datasets, in collaboration with the study team, and conducting quantitative analyses of the study data to address the study objectives.

Other information:

This project can be undertaken by a student based at the Liggins Institute (University of Auckland, New Zealand) or the Murdoch Children’s Research Institute (University of Melbourne, Australia).

Please note, this project is expected to start in 2019.

Funding notes:

If you have a GPA of 8.0 or more and you completed your most recent qualifying programme at a New Zealand university, you’ll be supported throughout your PhD study by a University of Auckland Doctoral Scholarship, which gives you a NZ$27,300 tax-free stipend (plus tuition fees) every year for three years. If your GPA is less than 8.0, there may still be scholarships available - you can discuss this with your potential supervisor or the academic director.

There are no international fees for PhD students: as long as you live in New Zealand during your period of enrolment you will pay the same as New Zealanders.

**Please include undergraduate and any postgraduate transcripts with your application.**