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  The role of chaperone networks in skin ageing


   Department of Biosciences

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  Dr A Benham  No more applications being accepted  Competition Funded PhD Project (European/UK Students Only)

About the Project

Our skin covers our bodies and performs an amazing range of functions, including protecting us from infection, controlling our temperature, and sensing our environment. Our skin is subjected to a wide range of stresses as we go through life, so how can we maintain healthy looking skin in the modern, stressful world? In on-going research, academics at Durham University, in collaboration with Procter and Gamble, have identified a new stress-responsive cellular pathway that becomes down-regulated when skin ages. In this project, the student will work with academia and industry to understand the molecular consequences of stress responses in skin cells. Using a range of techniques, the student will employ chemical approaches to activate or inhibit regulatory protein quality control networks in skin cells and apply the findings to tissue culture skin models. The work will help us to understand how stress causes skin ageing, and to develop interventional approaches to help protect skin from premature ageing.

For further information see the website: https://www.dur.ac.uk/biosciences/

To apply:
Please submit a full CV and covering letter directly to [Email Address Removed]



Funding Notes

This is a 4 year BBSRC iCASE studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£14,296 for 2016-17). The PhD will start in October 2017. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. There are 2 stages to the application process.

References

Tokuhiro, K., et. al. (2015). Calreticulin is required for development of the cumulus oocyte complex and female fertility. Scientific Reports 5: 14254.